Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2094365..2095022 Replicon chromosome
Accession NZ_CP017994
Organism Klebsiella pneumoniae strain P1428

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag BMF28_RS10390 Protein ID WP_002916310.1
Coordinates 2094365..2094775 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag BMF28_RS10395 Protein ID WP_002916312.1
Coordinates 2094756..2095022 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMF28_RS10370 2090365..2092098 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
BMF28_RS10375 2092104..2092817 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BMF28_RS10380 2092840..2093736 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
BMF28_RS10385 2093837..2094358 + 522 WP_002916308.1 flavodoxin FldB -
BMF28_RS10390 2094365..2094775 - 411 WP_002916310.1 protein YgfX Toxin
BMF28_RS10395 2094756..2095022 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
BMF28_RS10400 2095268..2096251 + 984 WP_014906951.1 tRNA-modifying protein YgfZ -
BMF28_RS10405 2096350..2097009 - 660 WP_002916317.1 hemolysin III family protein -
BMF28_RS10410 2097173..2097484 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
BMF28_RS10415 2097534..2098262 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
BMF28_RS10420 2098381..2099814 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T68506 WP_002916310.1 NZ_CP017994:c2094775-2094365 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T68506 NZ_CP017994:c2094775-2094365 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT68506 WP_002916312.1 NZ_CP017994:c2095022-2094756 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT68506 NZ_CP017994:c2095022-2094756 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References