Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 14347..14918 Replicon plasmid pKPC-98f
Accession NZ_CP017993
Organism Enterobacter cloacae complex sp. ECNIH7

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag WM95_RS27020 Protein ID WP_011918375.1
Coordinates 14607..14918 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag WM95_RS27015 Protein ID WP_011787805.1
Coordinates 14347..14607 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM95_RS26995 10637..12127 + 1491 WP_011787801.1 SulP family inorganic anion transporter -
WM95_RS27000 12162..13016 + 855 WP_011787802.1 universal stress protein -
WM95_RS27005 13107..13439 + 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
WM95_RS27010 13557..14177 - 621 WP_011787804.1 recombinase family protein -
WM95_RS27015 14347..14607 + 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
WM95_RS27020 14607..14918 + 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM95_RS27025 14942..18022 + 3081 WP_011787830.1 Tn3 family transposase -
WM95_RS27030 18076..19200 + 1125 Protein_19 Tn3 family transposase -
WM95_RS27035 19220..19780 - 561 Protein_20 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaKPC-2 - 1..21186 21186


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T68494 WP_011918375.1 NZ_CP017993:14607-14918 [Enterobacter cloacae complex sp. ECNIH7]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T68494 NZ_CP017993:14607-14918 [Enterobacter cloacae complex sp. ECNIH7]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT68494 WP_011787805.1 NZ_CP017993:14347-14607 [Enterobacter cloacae complex sp. ECNIH7]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT68494 NZ_CP017993:14347-14607 [Enterobacter cloacae complex sp. ECNIH7]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References