Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 8453..9024 Replicon plasmid pENT-2c5
Accession NZ_CP017992
Organism Enterobacter cloacae complex sp. ECNIH7

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag WM95_RS26515 Protein ID WP_011918375.1
Coordinates 8453..8764 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag WM95_RS26520 Protein ID WP_011787805.1
Coordinates 8764..9024 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM95_RS26495 3721..4062 - 342 WP_042005197.1 hypothetical protein -
WM95_RS26500 4104..4835 - 732 WP_042005196.1 type-F conjugative transfer system pilin acetylase TraX -
WM95_RS26505 4832..5296 - 465 Protein_7 DUF2726 domain-containing protein -
WM95_RS26510 5349..8429 - 3081 WP_011787830.1 Tn3 family transposase -
WM95_RS26515 8453..8764 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM95_RS26520 8764..9024 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
WM95_RS26525 9194..9814 + 621 WP_011787804.1 recombinase family protein -
WM95_RS26530 9932..10264 - 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
WM95_RS26535 10355..11209 - 855 WP_011787802.1 universal stress protein -
WM95_RS26540 11244..12734 - 1491 WP_011787801.1 SulP family inorganic anion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..79045 79045


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T68493 WP_011918375.1 NZ_CP017992:c8764-8453 [Enterobacter cloacae complex sp. ECNIH7]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T68493 NZ_CP017992:c8764-8453 [Enterobacter cloacae complex sp. ECNIH7]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT68493 WP_011787805.1 NZ_CP017992:c9024-8764 [Enterobacter cloacae complex sp. ECNIH7]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT68493 NZ_CP017992:c9024-8764 [Enterobacter cloacae complex sp. ECNIH7]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References