Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 70219..70790 Replicon plasmid pENT-1ac
Accession NZ_CP017991
Organism Enterobacter cloacae complex sp. ECNIH7

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag WM95_RS26080 Protein ID WP_011918375.1
Coordinates 70479..70790 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag WM95_RS26075 Protein ID WP_011787805.1
Coordinates 70219..70479 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM95_RS26045 65593..65783 - 191 Protein_65 hypothetical protein -
WM95_RS26050 65867..66067 - 201 Protein_66 hypothetical protein -
WM95_RS26055 66509..67999 + 1491 WP_011787801.1 SulP family inorganic anion transporter -
WM95_RS26060 68034..68888 + 855 WP_011787802.1 universal stress protein -
WM95_RS26065 68979..69311 + 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
WM95_RS26070 69429..70049 - 621 WP_011787804.1 recombinase family protein -
WM95_RS26075 70219..70479 + 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
WM95_RS26080 70479..70790 + 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM95_RS26085 70814..73894 + 3081 WP_011787830.1 Tn3 family transposase -
WM95_RS26090 73949..74505 - 557 Protein_74 IS1 family transposase -
WM95_RS26100 74687..75676 + 990 WP_088545061.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..144025 144025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T68492 WP_011918375.1 NZ_CP017991:70479-70790 [Enterobacter cloacae complex sp. ECNIH7]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T68492 NZ_CP017991:70479-70790 [Enterobacter cloacae complex sp. ECNIH7]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT68492 WP_011787805.1 NZ_CP017991:70219-70479 [Enterobacter cloacae complex sp. ECNIH7]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT68492 NZ_CP017991:70219-70479 [Enterobacter cloacae complex sp. ECNIH7]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References