Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 4305655..4306226 Replicon chromosome
Accession NZ_CP017990
Organism Enterobacter cloacae complex sp. ECNIH7

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag WM95_RS21320 Protein ID WP_011918375.1
Coordinates 4305655..4305966 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag WM95_RS21325 Protein ID WP_011787805.1
Coordinates 4305966..4306226 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM95_RS21305 4300964..4302151 + 1188 WP_063409624.1 cystathionine beta-lyase -
WM95_RS21310 4302295..4302495 + 201 Protein_4103 DedA family protein -
WM95_RS21315 4302551..4305631 - 3081 WP_011787830.1 Tn3 family transposase -
WM95_RS21320 4305655..4305966 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM95_RS21325 4305966..4306226 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
WM95_RS21330 4306396..4307016 + 621 WP_011787804.1 recombinase family protein -
WM95_RS21335 4307134..4307466 - 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
WM95_RS21340 4307557..4308240 - 684 Protein_4109 universal stress protein -
WM95_RS21345 4308295..4308999 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
WM95_RS21350 4309083..4309967 - 885 WP_000155092.1 Mph(E) family macrolide 2'-phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T68489 WP_011918375.1 NZ_CP017990:c4305966-4305655 [Enterobacter cloacae complex sp. ECNIH7]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T68489 NZ_CP017990:c4305966-4305655 [Enterobacter cloacae complex sp. ECNIH7]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT68489 WP_011787805.1 NZ_CP017990:c4306226-4305966 [Enterobacter cloacae complex sp. ECNIH7]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT68489 NZ_CP017990:c4306226-4305966 [Enterobacter cloacae complex sp. ECNIH7]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References