Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4113884..4114541 Replicon chromosome
Accession NZ_CP017990
Organism Enterobacter cloacae complex sp. ECNIH7

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag WM95_RS20310 Protein ID WP_021242050.1
Coordinates 4113884..4114294 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag WM95_RS20315 Protein ID WP_010435322.1
Coordinates 4114275..4114541 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM95_RS20290 4109877..4111610 - 1734 WP_045355605.1 single-stranded-DNA-specific exonuclease RecJ -
WM95_RS20295 4111616..4112329 - 714 WP_063408211.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
WM95_RS20300 4112358..4113254 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
WM95_RS20305 4113356..4113877 + 522 WP_063408212.1 flavodoxin FldB -
WM95_RS20310 4113884..4114294 - 411 WP_021242050.1 protein YgfX Toxin
WM95_RS20315 4114275..4114541 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
WM95_RS20320 4114836..4115816 + 981 WP_029739202.1 tRNA-modifying protein YgfZ -
WM95_RS20325 4115890..4116549 - 660 WP_023309101.1 hemolysin III family protein -
WM95_RS20330 4116715..4117026 - 312 WP_023309102.1 N(4)-acetylcytidine aminohydrolase -
WM95_RS20335 4117078..4117809 + 732 WP_063408213.1 MurR/RpiR family transcriptional regulator -
WM95_RS20340 4117926..4119359 + 1434 WP_063408214.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T68488 WP_021242050.1 NZ_CP017990:c4114294-4113884 [Enterobacter cloacae complex sp. ECNIH7]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T68488 NZ_CP017990:c4114294-4113884 [Enterobacter cloacae complex sp. ECNIH7]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAAACGA
CGCAGGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT68488 WP_010435322.1 NZ_CP017990:c4114541-4114275 [Enterobacter cloacae complex sp. ECNIH7]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT68488 NZ_CP017990:c4114541-4114275 [Enterobacter cloacae complex sp. ECNIH7]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTTGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References