Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 2856819..2857390 Replicon chromosome
Accession NZ_CP017990
Organism Enterobacter cloacae complex sp. ECNIH7

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag WM95_RS14065 Protein ID WP_011918375.1
Coordinates 2857079..2857390 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag WM95_RS14060 Protein ID WP_011787805.1
Coordinates 2856819..2857079 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM95_RS14035 2851874..2852611 - 738 Protein_2705 porin -
WM95_RS14040 2853109..2854599 + 1491 WP_011787801.1 SulP family inorganic anion transporter -
WM95_RS14045 2854634..2855488 + 855 WP_011787802.1 universal stress protein -
WM95_RS14050 2855579..2855911 + 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
WM95_RS14055 2856029..2856649 - 621 WP_011787804.1 recombinase family protein -
WM95_RS14060 2856819..2857079 + 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
WM95_RS14065 2857079..2857390 + 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM95_RS14070 2857414..2860494 + 3081 WP_011787830.1 Tn3 family transposase -
WM95_RS14075 2860550..2860897 - 348 Protein_2713 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T68478 WP_011918375.1 NZ_CP017990:2857079-2857390 [Enterobacter cloacae complex sp. ECNIH7]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T68478 NZ_CP017990:2857079-2857390 [Enterobacter cloacae complex sp. ECNIH7]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT68478 WP_011787805.1 NZ_CP017990:2856819-2857079 [Enterobacter cloacae complex sp. ECNIH7]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT68478 NZ_CP017990:2856819-2857079 [Enterobacter cloacae complex sp. ECNIH7]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References