Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 551546..552062 Replicon chromosome
Accession NZ_CP017990
Organism Enterobacter cloacae complex sp. ECNIH7

Toxin (Protein)


Gene name relE Uniprot ID A0A1Z3MQL4
Locus tag WM95_RS02700 Protein ID WP_063409469.1
Coordinates 551778..552062 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag WM95_RS02695 Protein ID WP_008501400.1
Coordinates 551546..551788 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM95_RS02680 547633..548373 + 741 WP_029739262.1 KDGP aldolase family protein -
WM95_RS02685 548399..549535 + 1137 WP_063409470.1 lactonase family protein -
WM95_RS02690 549558..551468 + 1911 WP_023310188.1 BglG family transcription antiterminator -
WM95_RS02695 551546..551788 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
WM95_RS02700 551778..552062 + 285 WP_063409469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM95_RS02705 552066..552530 - 465 WP_063409468.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
WM95_RS02710 552689..554827 - 2139 WP_023310191.1 anaerobic ribonucleoside-triphosphate reductase -
WM95_RS02715 555204..556847 - 1644 WP_063409467.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-81)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10870.74 Da        Isoelectric Point: 10.0531

>T68473 WP_063409469.1 NZ_CP017990:551778-552062 [Enterobacter cloacae complex sp. ECNIH7]
MTYELAFDPMALKEWCKLGQTVKDQFKKKLADVLVNPRVESARLHGLPDCYKIKLRTQGYRLVYQVQDNVVTVFAIAIGK
REKSAVYHDANKRL

Download         Length: 285 bp

>T68473 NZ_CP017990:551778-552062 [Enterobacter cloacae complex sp. ECNIH7]
ATGACTTATGAACTGGCATTTGACCCGATGGCGTTAAAGGAGTGGTGCAAGCTGGGGCAGACTGTAAAAGACCAGTTTAA
GAAGAAACTTGCGGACGTGCTGGTGAACCCCAGGGTCGAATCGGCCCGCCTGCATGGTCTGCCGGATTGCTACAAAATAA
AACTCAGAACGCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTAACGGTATTTGCTATCGCTATCGGTAAG
CGAGAGAAATCAGCCGTTTATCATGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT68473 WP_008501400.1 NZ_CP017990:551546-551788 [Enterobacter cloacae complex sp. ECNIH7]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT68473 NZ_CP017990:551546-551788 [Enterobacter cloacae complex sp. ECNIH7]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACCCC
AACGGAAGCCGTGCGATTACTGTTTCAGTACGTCGCGGAGACGGGACGTATGCCGGTGAAAACGGTCACGATTAGCGACA
GTGAAGATGCGCTGATACAGACGGTCCGGGAGCGACTGGCGAATCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3MQL4

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References