68469

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 19943..20465 Replicon plasmid unnamed1
Accession NZ_CP017986
Organism Klebsiella pneumoniae strain 825795-1

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag BB783_RS27705 Protein ID WP_004181778.1
Coordinates 19943..20227 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag BB783_RS27710 Protein ID WP_004181777.1
Coordinates 20217..20465 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB783_RS32585 15604..15810 + 207 WP_063938351.1 hypothetical protein -
BB783_RS32590 15855..16322 - 468 WP_124737156.1 hypothetical protein -
BB783_RS27695 16988..18175 + 1188 WP_004181780.1 transposase -
BB783_RS27700 18566..19789 - 1224 WP_004181779.1 transposase -
BB783_RS31460 19825..19926 + 102 Protein_14 IS200/IS605 family transposase -
BB783_RS27705 19943..20227 - 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BB783_RS27710 20217..20465 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BB783_RS27715 20756..22555 + 1800 WP_038991636.1 ATP-dependent helicase -
BB783_RS27720 22889..23875 + 987 WP_040120328.1 hypothetical protein -
BB783_RS27725 24020..24373 + 354 WP_004181774.1 hypothetical protein -
BB783_RS27730 24435..25256 + 822 WP_004026535.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..244706 244706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T68469 WP_004181778.1 NZ_CP017986:c20227-19943 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T68469 NZ_CP017986:c20227-19943 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT68469 WP_004181777.1 NZ_CP017986:c20465-20217 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT68469 NZ_CP017986:c20465-20217 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References