Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1474249..1474985 Replicon chromosome
Accession NZ_CP017985
Organism Klebsiella pneumoniae strain 825795-1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag BB783_RS07650 Protein ID WP_071836879.1
Coordinates 1474503..1474985 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag BB783_RS07645 Protein ID WP_003026799.1
Coordinates 1474249..1474515 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB783_RS07620 1469895..1471034 + 1140 WP_032433368.1 mannitol dehydrogenase -
BB783_RS07625 1471063..1471725 + 663 WP_032433366.1 dihydroxyacetone kinase subunit L -
BB783_RS07630 1471709..1472713 + 1005 WP_032433364.1 dihydroxyacetone kinase subunit DhaK -
BB783_RS07635 1472731..1473363 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
BB783_RS07640 1473373..1473936 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
BB783_RS07645 1474249..1474515 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
BB783_RS07650 1474503..1474985 + 483 WP_071836879.1 GNAT family N-acetyltransferase Toxin
BB783_RS07655 1475143..1476675 - 1533 WP_015065592.1 IS3-like element ISKpn38 family transposase -
BB783_RS07660 1476787..1478190 + 1404 WP_039815096.1 ISNCY-like element ISKpn21 family transposase -
BB783_RS07665 1478219..1478851 - 633 WP_001567369.1 hypothetical protein -
BB783_RS07670 1479231..1479830 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1442194..1489813 47619


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(80-149)

Antitoxin

(6-82)


Sequences


Toxin        


Download         Length: 161 a.a.        Molecular weight: 17481.06 Da        Isoelectric Point: 9.8177

>T68454 WP_071836879.1 NZ_CP017985:1474503-1474985 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVYKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

>T68454 NZ_CP017985:1474503-1474985 [Klebsiella pneumoniae]
GTGGGACGTGTAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTTGA
TGAATGGCTAAAGCACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTACAAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAACTACAGGCAGACTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCCGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT68454 WP_003026799.1 NZ_CP017985:1474249-1474515 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT68454 NZ_CP017985:1474249-1474515 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCTTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References