Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4509487..4510139 Replicon chromosome
Accession NZ_CP017969
Organism Pseudomonas aeruginosa isolate B10W

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BMR72_RS21765 Protein ID WP_003134109.1
Coordinates 4509487..4509897 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BMR72_RS21770 Protein ID WP_170869361.1
Coordinates 4509897..4510139 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMR72_RS32620 4505769..4506233 - 465 WP_154070642.1 hypothetical protein -
BMR72_RS21730 4506490..4507218 + 729 WP_023094843.1 TIGR03761 family integrating conjugative element protein -
BMR72_RS21735 4507224..4507757 + 534 WP_003134105.1 DUF3158 family protein -
BMR72_RS21740 4507771..4508259 + 489 WP_003134107.1 single-stranded DNA-binding protein -
BMR72_RS21745 4508363..4508557 + 195 WP_031632157.1 hypothetical protein -
BMR72_RS21750 4508809..4508976 + 168 WP_128729268.1 CrpP family protein -
BMR72_RS21760 4509277..4509471 - 195 WP_023094845.1 hypothetical protein -
BMR72_RS21765 4509487..4509897 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
BMR72_RS21770 4509897..4510139 - 243 WP_170869361.1 antitoxin Antitoxin
BMR72_RS21775 4510445..4512364 + 1920 WP_003134111.1 type I DNA topoisomerase -
BMR72_RS21780 4512372..4513124 + 753 Protein_4201 hypothetical protein -
BMR72_RS21785 4513241..4513846 - 606 WP_023094848.1 LysE family translocator -
BMR72_RS21790 4513968..4514837 + 870 WP_023094849.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - katA 4492177..4610785 118608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(11-37)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T68410 WP_003134109.1 NZ_CP017969:c4509897-4509487 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T68410 NZ_CP017969:c4509897-4509487 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACCATCAAAAACCGTCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGTCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8909.94 Da        Isoelectric Point: 4.4230

>AT68410 WP_170869361.1 NZ_CP017969:c4510139-4509897 [Pseudomonas aeruginosa]
MRCVVEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 243 bp

>AT68410 NZ_CP017969:c4510139-4509897 [Pseudomonas aeruginosa]
ATGAGGTGTGTCGTGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCCGTCGCGCT
TCCTGATGACGTTAAGCGTGTGGATGTGGTCGCTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGTGAGTCTTGGGATA
GCTGGTTCGATGGCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References