Detailed information of TA system TA068393

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2378191..2378828
• Replicon: chromosome
• Accession: NZ_CP017946
• Organism: Bosea sp. Tri-49

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BLM15_RS11800
• Protein ID: WP_126112933.1
• Coordinates: 2378424..2378828 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BLM15_RS11795
• Protein ID: WP_126112932.1
• Coordinates: 2378191..2378427 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLM15_RS31355	2373502..2373651	+	150	WP_164547487.1	hypothetical protein	-
BLM15_RS11770	2373668..2374588	-	921	WP_126112927.1	AEC family transporter	-
BLM15_RS11775	2374749..2375204	-	456	WP_164547488.1	thermonuclease family protein	-
BLM15_RS11780	2375387..2376907	+	1521	WP_126112929.1	HAMP domain-containing histidine kinase	-
BLM15_RS11785	2376919..2377266	-	348	WP_126112930.1	helix-turn-helix transcriptional regulator	-
BLM15_RS11790	2377374..2378078	+	705	WP_126112931.1	glutathione S-transferase family protein	-
BLM15_RS11795	2378191..2378427	+	237	WP_126112932.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BLM15_RS11800	2378424..2378828	+	405	WP_126112933.1	PIN domain-containing protein	Toxin
BLM15_RS11805	2378842..2379873	-	1032	WP_126112934.1	nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	-
BLM15_RS11810	2380020..2380823	+	804	WP_206438664.1	adenosylcobinamide-GDP ribazoletransferase	-
BLM15_RS11815	2380820..2381020	+	201	WP_126112936.1	DUF1289 domain-containing protein	-
BLM15_RS11820	2380977..2381444	-	468	WP_126112937.1	GNAT family N-acetyltransferase	-
BLM15_RS11825	2381456..2382289	-	834	WP_126116146.1	sulfite exporter TauE/SafE family protein	-
BLM15_RS11830	2382421..2382928	-	508	Protein_2351	DsrE family protein	-
BLM15_RS11835	2382954..2383454	-	501	WP_126112938.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-115)

Antitoxin

• SpoVT-AbrB domain (5-43)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14876.77 Da
• Isoelectric Point: 4.3689

>T68393 WP_126112933.1 NZ_CP017946:2378424-2378828 [Bosea sp. Tri-49]
VTRAFLDSNVVIYAFSDDPRNSVAEDLLGRGCELSVQVLNEFTNVARRKLGFSWAEITDAVEAITTLSRIVHPLGFATHQ
EAVRLAERYGLGFYDTLIVASALQSGCAVLYSEDMQHALIVDEQLRIENPFQAE

Nucleotide

• Length: 405 bp

>T68393 NZ_CP017946:2378424-2378828 [Bosea sp. Tri-49]
GTGACGCGCGCCTTTCTCGACAGCAATGTGGTGATCTACGCCTTCAGCGACGATCCACGGAACTCTGTGGCAGAGGATCT
GCTTGGCCGCGGCTGCGAGCTCAGCGTCCAGGTCCTGAACGAATTCACCAATGTTGCGCGCCGCAAGCTGGGCTTCTCAT
GGGCGGAGATCACTGACGCGGTCGAGGCGATCACGACGCTCAGCCGCATCGTCCATCCGCTCGGTTTCGCCACGCACCAA
GAGGCCGTCAGGCTGGCCGAGCGCTACGGATTGGGCTTCTACGACACATTGATCGTAGCGAGCGCGCTACAATCGGGCTG
TGCGGTGCTCTACAGCGAAGACATGCAGCACGCCCTGATCGTCGACGAGCAGCTGAGGATCGAGAATCCGTTCCAGGCGG
AGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8919.24 Da
• Isoelectric Point: 10.9040

>AT68393 WP_126112932.1 NZ_CP017946:2378191-2378427 [Bosea sp. Tri-49]
MQVARWGNSLAIRIPAAVSEALALKEGDDVDIRIADDRTFLIARDERKPRALARIRSLRKPLPPGWRFDRDEANERVP

Nucleotide

• Length: 237 bp

>AT68393 NZ_CP017946:2378191-2378427 [Bosea sp. Tri-49]
ATGCAGGTCGCACGCTGGGGCAACAGCCTCGCCATTCGGATACCAGCGGCCGTCAGCGAGGCACTGGCGCTCAAGGAAGG
CGATGACGTCGATATCCGTATCGCGGACGATCGCACCTTCCTGATCGCGCGCGACGAGCGCAAGCCGCGCGCGCTCGCCC
GTATCCGCAGCCTGCGCAAGCCGCTCCCGCCCGGCTGGCGCTTCGATCGCGACGAGGCCAATGAGCGCGTCCCGTGA