Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2828563..2829152 Replicon chromosome
Accession NZ_CP017940
Organism Phyllobacterium zundukense strain Tri-48

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BLM14_RS14130 Protein ID WP_099999965.1
Coordinates 2828563..2828745 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BLM14_RS14135 Protein ID WP_099999967.1
Coordinates 2828760..2829152 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLM14_RS14115 2824416..2825087 - 672 WP_099999960.1 hypothetical protein -
BLM14_RS14120 2825282..2828200 - 2919 WP_099999962.1 isoleucine--tRNA ligase -
BLM14_RS14125 2828197..2828385 - 189 WP_099999963.1 hypothetical protein -
BLM14_RS14130 2828563..2828745 + 183 WP_099999965.1 type II toxin-antitoxin system HicA family toxin Toxin
BLM14_RS14135 2828760..2829152 + 393 WP_099999967.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BLM14_RS14140 2829156..2829998 - 843 WP_099999969.1 MipA/OmpV family protein -
BLM14_RS14145 2830102..2831082 - 981 WP_099999971.1 bifunctional riboflavin kinase/FAD synthetase -
BLM14_RS14150 2831095..2831943 - 849 WP_100001334.1 TIGR01459 family HAD-type hydrolase -
BLM14_RS14155 2832057..2832386 - 330 WP_099999973.1 helix-turn-helix transcriptional regulator -
BLM14_RS14160 2832523..2833227 + 705 WP_100001336.1 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6934.13 Da        Isoelectric Point: 10.9985

>T68388 WP_099999965.1 NZ_CP017940:2828563-2828745 [Phyllobacterium zundukense]
MERDSRKIIKRLKDEGYELISVRGSHHKFRKGEKTLILPHPKRDLPLGTARAIAKDAGWL

Download         Length: 183 bp

>T68388 NZ_CP017940:2828563-2828745 [Phyllobacterium zundukense]
ATGGAACGCGACAGCCGGAAGATAATAAAGCGGCTAAAGGATGAAGGATATGAACTTATTTCGGTACGCGGTTCTCACCA
CAAATTCCGCAAGGGTGAAAAGACATTGATCCTCCCTCACCCGAAAAGGGACCTTCCGCTAGGGACGGCGCGAGCTATTG
CGAAAGACGCCGGTTGGCTATGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14165.83 Da        Isoelectric Point: 4.2249

>AT68388 WP_099999967.1 NZ_CP017940:2828760-2829152 [Phyllobacterium zundukense]
MRHYFALVHKDDDSAYGMQFPDFPGVYSAADSQDEIIFNAIEALRLYAEDSELSAPLELETVLEQNGVREQLAAGAYLVS
VPLIDNDTATVRVNVSFERGVLRAIDDTAGKRGLTRAAFLASAAKQAIEA

Download         Length: 393 bp

>AT68388 NZ_CP017940:2828760-2829152 [Phyllobacterium zundukense]
ATGCGGCACTACTTTGCCTTGGTGCACAAGGACGACGACAGCGCCTATGGCATGCAGTTTCCTGATTTTCCCGGCGTTTA
TTCAGCGGCCGATAGTCAGGATGAGATCATATTCAACGCCATTGAAGCGCTACGCCTTTATGCCGAAGACAGCGAATTGA
GCGCGCCCTTGGAGCTGGAGACCGTGCTTGAGCAGAACGGTGTGCGCGAGCAATTGGCCGCGGGCGCTTATCTGGTCTCA
GTGCCACTGATCGACAATGATACGGCGACTGTCCGGGTCAATGTCAGTTTCGAGCGCGGCGTCCTGCGCGCAATCGACGA
CACAGCAGGAAAACGCGGGCTTACCCGCGCTGCGTTCCTTGCCAGTGCTGCCAAGCAGGCTATCGAAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References