Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1540766..1541346 Replicon chromosome
Accession NZ_CP017940
Organism Phyllobacterium zundukense strain Tri-48

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BLM14_RS07685 Protein ID WP_099998836.1
Coordinates 1540766..1541020 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BLM14_RS07690 Protein ID WP_099998837.1
Coordinates 1541017..1541346 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLM14_RS07665 1536447..1537730 + 1284 WP_099998832.1 serine--tRNA ligase -
BLM14_RS07670 1537746..1538504 + 759 WP_099998833.1 5'/3'-nucleotidase SurE -
BLM14_RS07675 1538501..1539154 + 654 WP_099998834.1 protein-L-isoaspartate(D-aspartate) O-methyltransferase -
BLM14_RS07680 1539280..1540647 + 1368 WP_099998835.1 peptidoglycan DD-metalloendopeptidase family protein -
BLM14_RS07685 1540766..1541020 + 255 WP_099998836.1 type II toxin-antitoxin system HicA family toxin Toxin
BLM14_RS07690 1541017..1541346 + 330 WP_099998837.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BLM14_RS07695 1541363..1542226 - 864 WP_099998838.1 ATP-binding protein -
BLM14_RS07700 1542387..1542728 + 342 WP_099998839.1 preprotein translocase subunit YajC -
BLM14_RS07705 1542791..1545061 + 2271 WP_099998840.1 protein translocase subunit SecD -
BLM14_RS07710 1545063..1545452 + 390 WP_099998841.1 Mth938-like domain-containing protein -
BLM14_RS07715 1545480..1546316 + 837 WP_099998842.1 phytoene/squalene synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9390.70 Da        Isoelectric Point: 10.9288

>T68385 WP_099998836.1 NZ_CP017940:1540766-1541020 [Phyllobacterium zundukense]
MNSRHRRTLAAVFADPVSGSIAWSDIESLLISVGARTIEGSGSRVKFEKDGEVESFHRPHPSKEAKRYQVRAARVFLERI
GIKP

Download         Length: 255 bp

>T68385 NZ_CP017940:1540766-1541020 [Phyllobacterium zundukense]
ATGAACAGCAGACACAGACGGACCTTGGCGGCTGTCTTTGCGGACCCGGTTTCAGGTTCCATTGCATGGTCAGATATTGA
AAGTTTGCTGATCAGCGTGGGGGCACGAACGATCGAGGGTAGTGGGTCGCGTGTAAAATTTGAAAAAGATGGAGAAGTGG
AAAGCTTTCATCGGCCTCACCCCTCCAAGGAAGCAAAGCGTTACCAGGTGCGTGCGGCTCGGGTCTTTTTGGAGAGAATT
GGAATAAAGCCATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12297.86 Da        Isoelectric Point: 5.2050

>AT68385 WP_099998837.1 NZ_CP017940:1541017-1541346 [Phyllobacterium zundukense]
MNVMHYKDYTARIEYDDEDEIFFGKIADISDGVGFHADTVADLKVAFHEAVDDYIETCTKIGKQPQKPYSGKMMFRVKPE
IHRRAALAAERAGKSLNQWAEEALDKAAG

Download         Length: 330 bp

>AT68385 NZ_CP017940:1541017-1541346 [Phyllobacterium zundukense]
ATGAACGTCATGCACTACAAAGACTACACCGCGCGCATCGAATACGACGATGAGGATGAAATTTTCTTCGGCAAAATTGC
TGATATCAGCGATGGTGTCGGTTTTCATGCCGATACGGTAGCAGACTTGAAAGTGGCATTTCATGAAGCTGTCGATGACT
ATATCGAGACATGCACCAAAATCGGCAAGCAGCCCCAAAAGCCATATTCGGGCAAAATGATGTTTCGGGTAAAGCCTGAA
ATTCACCGCCGAGCGGCGCTTGCTGCAGAGCGAGCCGGCAAGAGCCTCAATCAATGGGCTGAAGAGGCATTGGACAAGGC
GGCGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References