Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4148982..4149639 Replicon chromosome
Accession NZ_CP017934
Organism Klebsiella pneumoniae strain CAV1016

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AGE75_RS20745 Protein ID WP_002916310.1
Coordinates 4149229..4149639 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AGE75_RS20740 Protein ID WP_002916312.1
Coordinates 4148982..4149248 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGE75_RS20715 4144138..4145571 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
AGE75_RS20720 4145690..4146418 - 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
AGE75_RS20725 4146468..4146779 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
AGE75_RS20730 4146943..4147602 + 660 WP_002916317.1 hemolysin III family protein -
AGE75_RS20735 4147753..4148736 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
AGE75_RS20740 4148982..4149248 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AGE75_RS20745 4149229..4149639 + 411 WP_002916310.1 protein YgfX Toxin
AGE75_RS20750 4149646..4150167 - 522 WP_002916308.1 flavodoxin FldB -
AGE75_RS20755 4150268..4151164 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AGE75_RS20760 4151187..4151900 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AGE75_RS20765 4151906..4153639 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T68374 WP_002916310.1 NZ_CP017934:4149229-4149639 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T68374 NZ_CP017934:4149229-4149639 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT68374 WP_002916312.1 NZ_CP017934:4148982-4149248 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT68374 NZ_CP017934:4148982-4149248 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References