Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1979761..1980380 Replicon chromosome
Accession NZ_CP017934
Organism Klebsiella pneumoniae strain CAV1016

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag AGE75_RS09830 Protein ID WP_002892050.1
Coordinates 1980162..1980380 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag AGE75_RS09825 Protein ID WP_002892066.1
Coordinates 1979761..1980135 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGE75_RS09815 1974913..1976106 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AGE75_RS09820 1976129..1979275 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
AGE75_RS09825 1979761..1980135 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
AGE75_RS09830 1980162..1980380 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
AGE75_RS09835 1980539..1981105 + 567 WP_002892030.1 maltose O-acetyltransferase -
AGE75_RS30275 1981077..1981217 - 141 WP_004147370.1 hypothetical protein -
AGE75_RS09845 1981238..1981708 + 471 WP_002892026.1 YlaC family protein -
AGE75_RS09850 1981683..1983089 - 1407 WP_020316531.1 PLP-dependent aminotransferase family protein -
AGE75_RS09855 1983234..1983932 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
AGE75_RS09860 1983929..1984069 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
AGE75_RS09865 1984069..1984332 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T68368 WP_002892050.1 NZ_CP017934:1980162-1980380 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T68368 NZ_CP017934:1980162-1980380 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT68368 WP_002892066.1 NZ_CP017934:1979761-1980135 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT68368 NZ_CP017934:1979761-1980135 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References