Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3556139..3556796 Replicon chromosome
Accession NZ_CP017928
Organism Klebsiella oxytoca strain CAV1015

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag AGF18_RS16515 Protein ID WP_004105559.1
Coordinates 3556139..3556549 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag AGF18_RS16520 Protein ID WP_004105561.1
Coordinates 3556530..3556796 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGF18_RS16495 3552116..3553849 - 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -
AGF18_RS16500 3553855..3554568 - 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AGF18_RS16505 3554591..3555487 - 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
AGF18_RS16510 3555609..3556130 + 522 WP_004105557.1 flavodoxin FldB -
AGF18_RS16515 3556139..3556549 - 411 WP_004105559.1 protein YgfX Toxin
AGF18_RS16520 3556530..3556796 - 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
AGF18_RS16525 3557040..3558023 + 984 WP_004115279.1 tRNA-modifying protein YgfZ -
AGF18_RS16530 3558151..3558810 - 660 WP_004105569.1 hemolysin III family protein -
AGF18_RS16535 3558972..3559283 - 312 WP_017145456.1 N(4)-acetylcytidine aminohydrolase -
AGF18_RS16540 3559334..3560062 + 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
AGF18_RS16545 3560183..3561616 + 1434 WP_004105576.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T68363 WP_004105559.1 NZ_CP017928:c3556549-3556139 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T68363 NZ_CP017928:c3556549-3556139 [Klebsiella oxytoca]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAATGGTTCTCACTGTTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTGTTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCAGACAGGGGGAAATAAAGTTGCTGATTGACTCTCGCCTGCGCTGGCAAAAAGCG
GAGTGGGATATCGTCGGCACCCCGTGGGTAATCAATAGCGGAATGCTGCTGCGTCTGCGAAATACGGAAAACCAACGCAC
TCAGCATCTATGGGTGGCGGCGGATAGCATGGACGCGGGCGAGTGGCGCGATCTGCGTCGGCTGGTGTTACAGAAACCGA
CGCAAGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT68363 WP_004105561.1 NZ_CP017928:c3556796-3556530 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT68363 NZ_CP017928:c3556796-3556530 [Klebsiella oxytoca]
ATGGATATTAACAATAAAGCTCGCATCCACTGGGCATGCCGCCGGGGAATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTTGAGCATGAGTACGATACGCTCAGTGATGACGATAAGCGGTTGTTCATCCGCCTGCTGGAAAATGACGATCCGGACC
TGTTCAACTGGTTGATGAACCATGGCGAACCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References