Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2675778..2676416 Replicon chromosome
Accession NZ_CP017928
Organism Klebsiella oxytoca strain CAV1015

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AGF18_RS12400 Protein ID WP_047043763.1
Coordinates 2675778..2675960 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AGF18_RS12405 Protein ID WP_047720836.1
Coordinates 2675985..2676416 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGF18_RS12365 2671345..2671764 - 420 WP_047720843.1 hypothetical protein -
AGF18_RS12370 2671764..2672096 - 333 WP_047720842.1 hypothetical protein -
AGF18_RS12375 2672187..2672372 - 186 WP_047720841.1 hypothetical protein -
AGF18_RS32860 2672829..2673086 + 258 WP_139153332.1 hypothetical protein -
AGF18_RS12380 2673870..2674100 - 231 WP_047720840.1 hypothetical protein -
AGF18_RS12385 2674331..2674798 - 468 WP_047720839.1 lysis protein -
AGF18_RS12390 2674801..2675223 - 423 WP_196557301.1 structural protein -
AGF18_RS12395 2675207..2675536 - 330 WP_139153342.1 phage holin, lambda family -
AGF18_RS12400 2675778..2675960 + 183 WP_047043763.1 type II toxin-antitoxin system HicA family toxin Toxin
AGF18_RS12405 2675985..2676416 + 432 WP_047720836.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AGF18_RS31625 2676646..2677248 - 603 WP_071845044.1 hypothetical protein -
AGF18_RS12410 2677261..2678322 - 1062 WP_047720835.1 DUF968 domain-containing protein -
AGF18_RS12415 2678319..2680166 - 1848 WP_047720834.1 DNA cytosine methyltransferase -
AGF18_RS12420 2680159..2681043 - 885 WP_047720833.1 phage N-6-adenine-methyltransferase -
AGF18_RS12425 2681043..2681300 - 258 WP_004122994.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2638423..2705842 67419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-137)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6508.74 Da        Isoelectric Point: 10.8930

>T68361 WP_047043763.1 NZ_CP017928:2675778-2675960 [Klebsiella oxytoca]
MKSTDLIKELIAAGCELKRQGKGSHQIWWSPITGKTFPVPHPKGNLPIGTIKSIKKTAGI

Download         Length: 183 bp

>T68361 NZ_CP017928:2675778-2675960 [Klebsiella oxytoca]
ATGAAATCGACTGACCTGATAAAGGAATTGATAGCCGCCGGATGTGAACTCAAAAGGCAAGGGAAAGGCAGTCACCAGAT
ATGGTGGTCGCCGATAACGGGAAAAACATTCCCGGTTCCACACCCTAAGGGCAACCTACCGATCGGCACCATCAAATCCA
TCAAGAAAACGGCGGGGATCTAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 16029.07 Da        Isoelectric Point: 4.2696

>AT68361 WP_047720836.1 NZ_CP017928:2675985-2676416 [Klebsiella oxytoca]
MFFSVGVETPKDENTAYGMIVPAFSAYEMGCFSAADTQDQIAPMVKEAILLSVECLVEDAGRSVDEIKDAGYMVYAANPE
YKDFDSWFMVEVDLSEFEGKPQRINISLPDTLIKRIDNAVKGNASYRDRSHFLAEAARHELKQ

Download         Length: 432 bp

>AT68361 NZ_CP017928:2675985-2676416 [Klebsiella oxytoca]
ATGTTCTTTTCAGTGGGCGTTGAGACGCCAAAAGATGAAAACACCGCCTACGGTATGATTGTTCCTGCGTTTTCAGCTTA
TGAGATGGGTTGCTTCTCCGCCGCTGATACACAGGACCAGATCGCGCCAATGGTTAAAGAAGCCATTCTCTTAAGCGTTG
AGTGCCTGGTCGAAGATGCAGGGCGCAGCGTCGATGAAATCAAAGACGCCGGCTATATGGTGTATGCAGCTAACCCAGAA
TATAAGGACTTTGACAGCTGGTTCATGGTTGAAGTTGATTTGTCTGAGTTCGAAGGCAAGCCACAACGTATCAATATTTC
ACTGCCTGATACGCTGATTAAGCGCATCGATAATGCTGTAAAGGGTAACGCCAGCTATCGAGACAGAAGCCATTTTCTGG
CTGAAGCTGCCCGACACGAACTGAAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References