Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 3009563..3010089 Replicon chromosome
Accession NZ_CP017920
Organism Mycobacterium tuberculosis strain TB282

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag BK419_RS14335 Protein ID WP_003401560.1
Coordinates 3009563..3009865 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag BK419_RS14340 Protein ID WP_003401555.1
Coordinates 3009862..3010089 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK419_RS14315 3007199..3008107 - 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -
BK419_RS14320 3008104..3008736 - 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
BK419_RS14325 3008872..3009297 - 426 WP_003401566.1 PIN domain nuclease -
BK419_RS14330 3009294..3009515 - 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
BK419_RS14335 3009563..3009865 - 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
BK419_RS14340 3009862..3010089 - 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
BK419_RS14345 3010232..3012007 - 1776 WP_010886074.1 PE family protein -
BK419_RS14350 3012186..3013583 + 1398 WP_003401544.1 sulfatase -
BK419_RS14355 3013593..3014396 + 804 WP_003401540.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(6-41)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T68336 WP_003401560.1 NZ_CP017920:c3009865-3009563 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T68336 NZ_CP017920:c3009865-3009563 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT68336 WP_003401555.1 NZ_CP017920:c3010089-3009862 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT68336 NZ_CP017920:c3010089-3009862 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References