Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 2675569..2676215 Replicon chromosome
Accession NZ_CP017920
Organism Mycobacterium tuberculosis strain TB282

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag BK419_RS12810 Protein ID WP_003403137.1
Coordinates 2675802..2676215 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag BK419_RS12805 Protein ID WP_003403139.1
Coordinates 2675569..2675805 (+) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK419_RS12770 2670643..2671353 - 711 Protein_2493 transposase -
BK419_RS12775 2671355..2671939 - 585 WP_003403171.1 IS607-like element IS1536 family transposase -
BK419_RS12780 2672180..2673130 - 951 WP_003900184.1 DUF1259 domain-containing protein -
BK419_RS12785 2673202..2673513 - 312 WP_003403164.1 hypothetical protein -
BK419_RS12790 2673570..2674331 + 762 WP_003403148.1 two-component system response regulator TcrA -
BK419_RS12795 2674315..2674845 + 531 WP_003917320.1 two component system sensor kinase HK2 -
BK419_RS12800 2674959..2675465 + 507 WP_003900973.1 two component system sensor kinase HK1 -
BK419_RS12805 2675569..2675805 + 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BK419_RS12810 2675802..2676215 + 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
BK419_RS12815 2676466..2677701 + 1236 WP_003403128.1 ATP-binding protein -
BK419_RS12820 2677884..2678141 + 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
BK419_RS12825 2678138..2678530 + 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
BK419_RS12830 2678582..2680132 - 1551 WP_003905349.1 MCE family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-126)

Antitoxin

(3-43)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T68329 WP_003403137.1 NZ_CP017920:2675802-2676215 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T68329 NZ_CP017920:2675802-2676215 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT68329 WP_003403139.1 NZ_CP017920:2675569-2675805 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT68329 NZ_CP017920:2675569-2675805 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ88


Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References