Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2656310..2656959 Replicon chromosome
Accession NZ_CP017920
Organism Mycobacterium tuberculosis strain TB282

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag BK419_RS12665 Protein ID WP_003403236.1
Coordinates 2656310..2656705 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag BK419_RS12670 Protein ID WP_003403235.1
Coordinates 2656705..2656959 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK419_RS12640 2651637..2653364 + 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -
BK419_RS12645 2653457..2654608 + 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
BK419_RS12650 2654680..2655087 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
BK419_RS12655 2655084..2655344 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BK419_RS12660 2655476..2656216 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
BK419_RS12665 2656310..2656705 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
BK419_RS12670 2656705..2656959 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
BK419_RS12675 2657052..2657999 - 948 WP_003403232.1 DUF732 domain-containing protein -
BK419_RS12680 2658103..2659167 - 1065 WP_003898532.1 hypothetical protein -
BK419_RS12690 2659562..2660653 - 1092 WP_003900977.1 galactokinase -
BK419_RS21605 2660650..2661141 - 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
BK419_RS21610 2661138..2661833 - 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T68326 WP_003403236.1 NZ_CP017920:c2656705-2656310 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T68326 NZ_CP017920:c2656705-2656310 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT68326 WP_003403235.1 NZ_CP017920:c2656959-2656705 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT68326 NZ_CP017920:c2656959-2656705 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References