Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 2617044..2617836 Replicon chromosome
Accession NZ_CP017920
Organism Mycobacterium tuberculosis strain TB282

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag BK419_RS12455 Protein ID WP_003403386.1
Coordinates 2617044..2617481 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag BK419_RS12460 Protein ID WP_003403381.1
Coordinates 2617591..2617836 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK419_RS12430 2613507..2613680 - 174 WP_003898549.1 hypothetical protein -
BK419_RS12435 2613677..2614015 - 339 WP_003403405.1 PIN domain-containing protein -
BK419_RS12440 2613927..2614253 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BK419_RS12445 2614316..2616679 - 2364 WP_003901895.1 arylsulfatase AtsD -
BK419_RS12450 2616793..2617047 + 255 WP_003911263.1 antitoxin VapB7 -
BK419_RS12455 2617044..2617481 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
BK419_RS12460 2617591..2617836 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
BK419_RS12465 2617823..2618131 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
BK419_RS12470 2618407..2619123 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
BK419_RS12475 2619199..2619354 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
BK419_RS12480 2619449..2619832 + 384 WP_003403365.1 ribonuclease VapC6 -
BK419_RS12485 2620220..2621230 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
BK419_RS12490 2621311..2622816 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T68322 WP_003403386.1 NZ_CP017920:2617044-2617481 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T68322 NZ_CP017920:2617044-2617481 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT68322 WP_003403381.1 NZ_CP017920:2617591-2617836 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT68322 NZ_CP017920:2617591-2617836 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References