68315

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1989427..1990115 Replicon chromosome
Accession NZ_CP017920
Organism Mycobacterium tuberculosis strain TB282

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag BK419_RS09340 Protein ID WP_003406304.1
Coordinates 1989427..1989858 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag BK419_RS09345 Protein ID WP_003406302.1
Coordinates 1989855..1990115 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK419_RS09315 1985254..1985523 + 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BK419_RS09320 1985520..1985813 + 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
BK419_RS09325 1985870..1986700 + 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
BK419_RS09330 1986781..1987641 - 861 WP_003900301.1 hypothetical protein -
BK419_RS09335 1987821..1989404 + 1584 WP_009940130.1 PE family protein -
BK419_RS09340 1989427..1989858 - 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
BK419_RS09345 1989855..1990115 - 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
BK419_RS09350 1990191..1991180 - 990 WP_003406301.1 malate dehydrogenase -
BK419_RS09355 1991351..1992451 + 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
BK419_RS09360 1992528..1993709 - 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
BK419_RS09365 1993714..1994538 - 825 WP_003900298.1 trehalose ABC transporter permease SugB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-142)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T68315 WP_003406304.1 NZ_CP017920:c1989858-1989427 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T68315 NZ_CP017920:c1989858-1989427 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT68315 WP_003406302.1 NZ_CP017920:c1990115-1989855 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT68315 NZ_CP017920:c1990115-1989855 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0THR7


Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References