Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1605807..1606420 Replicon chromosome
Accession NZ_CP017920
Organism Mycobacterium tuberculosis strain TB282

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag BK419_RS07630 Protein ID WP_003407786.1
Coordinates 1605807..1606211 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag BK419_RS07635 Protein ID WP_009935474.1
Coordinates 1606217..1606420 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK419_RS07620 1601758..1604055 + 2298 WP_003407790.1 malto-oligosyltrehalose synthase -
BK419_RS07625 1604048..1605790 + 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
BK419_RS07630 1605807..1606211 - 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
BK419_RS07635 1606217..1606420 - 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BK419_RS07640 1606473..1607762 - 1290 WP_003407781.1 threonine ammonia-lyase -
BK419_RS07645 1607797..1608243 - 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
BK419_RS07650 1608253..1609401 - 1149 Protein_1505 MMPL family transporter -
BK419_RS07655 1609585..1610193 - 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
BK419_RS07660 1610261..1610638 - 378 WP_003407771.1 fumarate reductase subunit FrdD -
BK419_RS07665 1610635..1611015 - 381 WP_003407768.1 fumarate reductase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T68310 WP_003407786.1 NZ_CP017920:c1606211-1605807 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T68310 NZ_CP017920:c1606211-1605807 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT68310 WP_009935474.1 NZ_CP017920:c1606420-1606217 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT68310 NZ_CP017920:c1606420-1606217 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References