Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-RHH |
Location | 1181255..1181799 | Replicon | chromosome |
Accession | NZ_CP017920 | ||
Organism | Mycobacterium tuberculosis strain TB282 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TLU9 |
Locus tag | BK419_RS05705 | Protein ID | WP_003409896.1 |
Coordinates | 1181503..1181799 (+) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P67299 |
Locus tag | BK419_RS05700 | Protein ID | WP_003409899.1 |
Coordinates | 1181255..1181506 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BK419_RS05670 | 1176982..1177779 | - | 798 | WP_003899101.1 | ABC transporter permease | - |
BK419_RS05680 | 1178678..1179898 | + | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
BK419_RS05685 | 1179931..1180203 | + | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
BK419_RS05690 | 1180207..1180614 | + | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
BK419_RS05695 | 1180774..1181268 | - | 495 | WP_003899099.1 | hypothetical protein | - |
BK419_RS05700 | 1181255..1181506 | + | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
BK419_RS05705 | 1181503..1181799 | + | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
BK419_RS05710 | 1181848..1182462 | + | 615 | WP_003901296.1 | hypothetical protein | - |
BK419_RS05715 | 1182351..1182896 | - | 546 | WP_003409891.1 | SecB-like chaperone | - |
BK419_RS05720 | 1182893..1183342 | - | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
BK419_RS05725 | 1183384..1183761 | - | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
BK419_RS22455 | 1183736..1184257 | + | 522 | WP_003904745.1 | hypothetical protein | - |
BK419_RS05735 | 1184231..1184542 | - | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
BK419_RS05740 | 1184539..1184754 | - | 216 | WP_003409878.1 | antitoxin | - |
BK419_RS05745 | 1184994..1185290 | + | 297 | WP_003409877.1 | hypothetical protein | - |
BK419_RS05750 | 1185291..1185482 | + | 192 | WP_003409876.1 | hypothetical protein | - |
BK419_RS05755 | 1185503..1186405 | + | 903 | WP_003899097.1 | hypothetical protein | - |
BK419_RS05760 | 1186416..1186766 | + | 351 | WP_003409871.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T68305 WP_003409896.1 NZ_CP017920:1181503-1181799 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T68305 NZ_CP017920:1181503-1181799 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT68305 WP_003409899.1 NZ_CP017920:1181255-1181506 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT68305 NZ_CP017920:1181255-1181506 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TLU9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BUZ2 |