Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1181255..1181799 Replicon chromosome
Accession NZ_CP017920
Organism Mycobacterium tuberculosis strain TB282

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag BK419_RS05705 Protein ID WP_003409896.1
Coordinates 1181503..1181799 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag BK419_RS05700 Protein ID WP_003409899.1
Coordinates 1181255..1181506 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK419_RS05670 1176982..1177779 - 798 WP_003899101.1 ABC transporter permease -
BK419_RS05680 1178678..1179898 + 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
BK419_RS05685 1179931..1180203 + 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BK419_RS05690 1180207..1180614 + 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
BK419_RS05695 1180774..1181268 - 495 WP_003899099.1 hypothetical protein -
BK419_RS05700 1181255..1181506 + 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BK419_RS05705 1181503..1181799 + 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BK419_RS05710 1181848..1182462 + 615 WP_003901296.1 hypothetical protein -
BK419_RS05715 1182351..1182896 - 546 WP_003409891.1 SecB-like chaperone -
BK419_RS05720 1182893..1183342 - 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
BK419_RS05725 1183384..1183761 - 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
BK419_RS22455 1183736..1184257 + 522 WP_003904745.1 hypothetical protein -
BK419_RS05735 1184231..1184542 - 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
BK419_RS05740 1184539..1184754 - 216 WP_003409878.1 antitoxin -
BK419_RS05745 1184994..1185290 + 297 WP_003409877.1 hypothetical protein -
BK419_RS05750 1185291..1185482 + 192 WP_003409876.1 hypothetical protein -
BK419_RS05755 1185503..1186405 + 903 WP_003899097.1 hypothetical protein -
BK419_RS05760 1186416..1186766 + 351 WP_003409871.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T68305 WP_003409896.1 NZ_CP017920:1181503-1181799 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T68305 NZ_CP017920:1181503-1181799 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT68305 WP_003409899.1 NZ_CP017920:1181255-1181506 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT68305 NZ_CP017920:1181255-1181506 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References