Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 3229963..3230510 Replicon chromosome
Accession NZ_CP017919
Organism Vibrio alginolyticus strain K09K1

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag K09K1_RS24220 Protein ID WP_005377013.1
Coordinates 3230208..3230510 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag K09K1_RS24215 Protein ID WP_005377012.1
Coordinates 3229963..3230220 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K09K1_RS24160 3225675..3226352 + 678 WP_054730736.1 hypothetical protein -
K09K1_RS24165 3226513..3226779 + 267 WP_054730732.1 hypothetical protein -
K09K1_RS24170 3226812..3226904 + 93 WP_078535132.1 DUF3265 domain-containing protein -
K09K1_RS24175 3227029..3227373 + 345 WP_054730730.1 antibiotic biosynthesis monooxygenase -
K09K1_RS24180 3227381..3227491 + 111 WP_085570176.1 DUF3265 domain-containing protein -
K09K1_RS24185 3227519..3227866 + 348 WP_005448158.1 nucleic acid-binding protein -
K09K1_RS24190 3227892..3227984 + 93 WP_079858050.1 DUF3265 domain-containing protein -
K09K1_RS24195 3228014..3228430 + 417 WP_033907128.1 DUF1311 domain-containing protein -
K09K1_RS24200 3228464..3228556 + 93 WP_080256086.1 DUF3265 domain-containing protein -
K09K1_RS25555 3228592..3228822 + 231 WP_157664342.1 hypothetical protein -
K09K1_RS24205 3228836..3229087 + 252 WP_054730722.1 hypothetical protein -
K09K1_RS24210 3229202..3229759 + 558 WP_054730719.1 hypothetical protein -
K09K1_RS24215 3229963..3230220 + 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K09K1_RS24220 3230208..3230510 + 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K09K1_RS24225 3230546..3230638 + 93 WP_086046818.1 DUF3265 domain-containing protein -
K09K1_RS24230 3230688..3231158 + 471 WP_054730714.1 GNAT family N-acetyltransferase -
K09K1_RS24235 3231188..3231280 + 93 WP_197687490.1 DUF3265 domain-containing protein -
K09K1_RS24240 3231319..3231807 + 489 WP_054730711.1 DUF523 domain-containing protein -
K09K1_RS24245 3231958..3232440 + 483 WP_017821432.1 hypothetical protein -
K09K1_RS24250 3232586..3233095 + 510 WP_005377035.1 GNAT family N-acetyltransferase -
K09K1_RS24255 3233110..3233202 + 93 WP_005526494.1 DUF3265 domain-containing protein -
K09K1_RS24260 3233230..3233706 + 477 WP_086046816.1 GNAT family N-acetyltransferase -
K09K1_RS24265 3233897..3234118 + 222 Protein_2880 transposase -
K09K1_RS24270 3234202..3235053 + 852 WP_054730937.1 IS3 family transposase -
K09K1_RS24275 3235115..3235438 + 324 WP_086046815.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vxsC / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 3026865..3443561 416696
- inside Integron - - 3214659..3234205 19546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T68282 WP_005377013.1 NZ_CP017919:3230208-3230510 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T68282 NZ_CP017919:3230208-3230510 [Vibrio alginolyticus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATCTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATTCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT68282 WP_005377012.1 NZ_CP017919:3229963-3230220 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT68282 NZ_CP017919:3229963-3230220 [Vibrio alginolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCGGATCTCCACGATACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGATAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References