Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1949698..1950245 Replicon chromosome
Accession NZ_CP017913
Organism Vibrio alginolyticus strain K08M3

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag K08M3_RS09100 Protein ID WP_005377013.1
Coordinates 1949698..1950000 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag K08M3_RS09105 Protein ID WP_005377012.1
Coordinates 1949988..1950245 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K08M3_RS09045 1944770..1945174 - 405 WP_157664343.1 hypothetical protein -
K08M3_RS09050 1945155..1946006 - 852 WP_054730937.1 IS3 family transposase -
K08M3_RS09055 1946090..1946311 - 222 Protein_1714 transposase -
K08M3_RS09060 1946502..1946978 - 477 WP_086046816.1 GNAT family N-acetyltransferase -
K08M3_RS09065 1947006..1947098 - 93 WP_005526494.1 DUF3265 domain-containing protein -
K08M3_RS09070 1947113..1947622 - 510 WP_005377035.1 GNAT family N-acetyltransferase -
K08M3_RS09075 1947768..1948250 - 483 WP_017821432.1 hypothetical protein -
K08M3_RS09080 1948401..1948889 - 489 WP_054730711.1 DUF523 domain-containing protein -
K08M3_RS09085 1948928..1949020 - 93 WP_197687490.1 DUF3265 domain-containing protein -
K08M3_RS09090 1949050..1949520 - 471 WP_054730714.1 GNAT family N-acetyltransferase -
K08M3_RS09095 1949570..1949662 - 93 WP_086046818.1 DUF3265 domain-containing protein -
K08M3_RS09100 1949698..1950000 - 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K08M3_RS09105 1949988..1950245 - 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K08M3_RS09110 1950449..1951006 - 558 WP_054730719.1 hypothetical protein -
K08M3_RS09115 1951121..1951372 - 252 WP_054730722.1 hypothetical protein -
K08M3_RS26720 1951386..1951616 - 231 WP_157664342.1 hypothetical protein -
K08M3_RS09120 1951652..1951744 - 93 WP_080256086.1 DUF3265 domain-containing protein -
K08M3_RS09125 1951778..1952194 - 417 WP_033907128.1 DUF1311 domain-containing protein -
K08M3_RS09130 1952224..1952316 - 93 WP_079858050.1 DUF3265 domain-containing protein -
K08M3_RS09135 1952342..1952689 - 348 WP_005448158.1 nucleic acid-binding protein -
K08M3_RS09140 1952717..1952827 - 111 WP_085570176.1 DUF3265 domain-containing protein -
K08M3_RS09145 1952835..1953179 - 345 WP_054730730.1 antibiotic biosynthesis monooxygenase -
K08M3_RS09150 1953304..1953396 - 93 WP_078535132.1 DUF3265 domain-containing protein -
K08M3_RS09155 1953429..1953695 - 267 WP_054730732.1 hypothetical protein -
K08M3_RS09160 1953856..1954533 - 678 WP_054730736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1934255..2078403 144148
- inside Integron - - 1946003..1965549 19546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T68277 WP_005377013.1 NZ_CP017913:c1950000-1949698 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T68277 NZ_CP017913:c1950000-1949698 [Vibrio alginolyticus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATCTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATTCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT68277 WP_005377012.1 NZ_CP017913:c1950245-1949988 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT68277 NZ_CP017913:c1950245-1949988 [Vibrio alginolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCGGATCTCCACGATACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGATAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References