Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1939988..1940535 Replicon chromosome
Accession NZ_CP017911
Organism Vibrio alginolyticus strain K10K4

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag K10K4_RS09075 Protein ID WP_005377013.1
Coordinates 1939988..1940290 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag K10K4_RS09080 Protein ID WP_005377012.1
Coordinates 1940278..1940535 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K10K4_RS09020 1935060..1935464 - 405 WP_157664343.1 hypothetical protein -
K10K4_RS09025 1935445..1936296 - 852 WP_054730937.1 IS3 family transposase -
K10K4_RS09030 1936380..1936601 - 222 Protein_1705 transposase -
K10K4_RS09035 1936792..1937268 - 477 WP_086046816.1 GNAT family N-acetyltransferase -
K10K4_RS09040 1937296..1937388 - 93 WP_005526494.1 DUF3265 domain-containing protein -
K10K4_RS09045 1937403..1937912 - 510 WP_005377035.1 GNAT family N-acetyltransferase -
K10K4_RS09050 1938058..1938540 - 483 WP_017821432.1 hypothetical protein -
K10K4_RS09055 1938691..1939179 - 489 WP_054730711.1 DUF523 domain-containing protein -
K10K4_RS09060 1939218..1939310 - 93 WP_197687490.1 DUF3265 domain-containing protein -
K10K4_RS09065 1939340..1939810 - 471 WP_054730714.1 GNAT family N-acetyltransferase -
K10K4_RS09070 1939860..1939952 - 93 WP_086046818.1 DUF3265 domain-containing protein -
K10K4_RS09075 1939988..1940290 - 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K10K4_RS09080 1940278..1940535 - 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K10K4_RS09085 1940739..1941296 - 558 WP_054730719.1 hypothetical protein -
K10K4_RS09090 1941411..1941662 - 252 WP_054730722.1 hypothetical protein -
K10K4_RS25285 1941676..1941906 - 231 WP_157664342.1 hypothetical protein -
K10K4_RS09095 1941942..1942034 - 93 WP_080256086.1 DUF3265 domain-containing protein -
K10K4_RS09100 1942068..1942484 - 417 WP_033907128.1 DUF1311 domain-containing protein -
K10K4_RS09105 1942514..1942606 - 93 WP_079858050.1 DUF3265 domain-containing protein -
K10K4_RS09110 1942632..1942979 - 348 WP_005448158.1 nucleic acid-binding protein -
K10K4_RS09115 1943007..1943117 - 111 WP_085570176.1 DUF3265 domain-containing protein -
K10K4_RS09120 1943125..1943469 - 345 WP_054730730.1 antibiotic biosynthesis monooxygenase -
K10K4_RS09125 1943594..1943686 - 93 WP_078535132.1 DUF3265 domain-containing protein -
K10K4_RS09130 1943719..1943985 - 267 WP_054730732.1 hypothetical protein -
K10K4_RS09135 1944146..1944823 - 678 WP_054730736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1924545..2068693 144148
- inside Integron - - 1936293..1955839 19546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T68276 WP_005377013.1 NZ_CP017911:c1940290-1939988 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T68276 NZ_CP017911:c1940290-1939988 [Vibrio alginolyticus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATCTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATTCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT68276 WP_005377012.1 NZ_CP017911:c1940535-1940278 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT68276 NZ_CP017911:c1940535-1940278 [Vibrio alginolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCGGATCTCCACGATACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGATAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References