Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1956432..1956979 Replicon chromosome
Accession NZ_CP017902
Organism Vibrio alginolyticus strain K05K4

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag K05K4_RS09235 Protein ID WP_005377013.1
Coordinates 1956432..1956734 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag K05K4_RS09240 Protein ID WP_005377012.1
Coordinates 1956722..1956979 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K05K4_RS09170 1951504..1951827 - 324 WP_086046815.1 hypothetical protein -
K05K4_RS09175 1951889..1952782 - 894 WP_107488250.1 IS3 family transposase -
K05K4_RS09180 1952824..1953045 - 222 Protein_1781 transposase -
K05K4_RS09185 1953236..1953712 - 477 WP_086046816.1 GNAT family N-acetyltransferase -
K05K4_RS09190 1953740..1953832 - 93 WP_005526494.1 DUF3265 domain-containing protein -
K05K4_RS09195 1953847..1954356 - 510 WP_005377035.1 GNAT family N-acetyltransferase -
K05K4_RS09200 1954393..1954487 - 95 Protein_1785 hypothetical protein -
K05K4_RS09205 1954502..1954984 - 483 WP_017821432.1 hypothetical protein -
K05K4_RS09210 1955003..1955092 - 90 Protein_1787 nitrate reductase -
K05K4_RS09215 1955135..1955623 - 489 WP_054730711.1 DUF523 domain-containing protein -
K05K4_RS09220 1955662..1955787 - 126 WP_086046817.1 DUF3265 domain-containing protein -
K05K4_RS09225 1955784..1956254 - 471 WP_054730714.1 GNAT family N-acetyltransferase -
K05K4_RS09230 1956304..1956396 - 93 WP_086046818.1 DUF3265 domain-containing protein -
K05K4_RS09235 1956432..1956734 - 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K05K4_RS09240 1956722..1956979 - 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K05K4_RS09245 1957183..1957740 - 558 WP_054730719.1 hypothetical protein -
K05K4_RS09250 1957855..1958106 - 252 WP_054730722.1 hypothetical protein -
K05K4_RS09255 1958386..1958478 - 93 WP_080256086.1 DUF3265 domain-containing protein -
K05K4_RS09260 1958512..1958928 - 417 WP_033907128.1 DUF1311 domain-containing protein -
K05K4_RS09265 1958958..1959050 - 93 WP_079858050.1 DUF3265 domain-containing protein -
K05K4_RS09270 1959076..1959423 - 348 WP_005448158.1 nucleic acid-binding protein -
K05K4_RS09275 1959451..1959540 - 90 WP_078558657.1 DUF3265 domain-containing protein -
K05K4_RS09280 1959569..1959913 - 345 WP_054730730.1 antibiotic biosynthesis monooxygenase -
K05K4_RS09285 1960038..1960130 - 93 WP_078535132.1 DUF3265 domain-containing protein -
K05K4_RS09290 1960163..1960429 - 267 WP_054730732.1 hypothetical protein -
K05K4_RS09295 1960590..1961267 - 678 WP_054730736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1940989..2085136 144147
- inside Integron - - 1952737..1972283 19546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T68272 WP_005377013.1 NZ_CP017902:c1956734-1956432 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T68272 NZ_CP017902:c1956734-1956432 [Vibrio alginolyticus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATCTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATTCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT68272 WP_005377012.1 NZ_CP017902:c1956979-1956722 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT68272 NZ_CP017902:c1956979-1956722 [Vibrio alginolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCGGATCTCCACGATACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGATAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References