Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1952482..1953029 Replicon chromosome
Accession NZ_CP017899
Organism Vibrio alginolyticus strain K04M5

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag K04M5_RS09090 Protein ID WP_005377013.1
Coordinates 1952482..1952784 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag K04M5_RS09095 Protein ID WP_005377012.1
Coordinates 1952772..1953029 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K04M5_RS09035 1947554..1947970 - 417 WP_157664637.1 hypothetical protein -
K04M5_RS09040 1947939..1948790 - 852 WP_054730937.1 IS3 family transposase -
K04M5_RS09045 1948874..1949095 - 222 Protein_1712 transposase -
K04M5_RS09050 1949286..1949762 - 477 WP_086046816.1 GNAT family N-acetyltransferase -
K04M5_RS09055 1949790..1949882 - 93 WP_005526494.1 DUF3265 domain-containing protein -
K04M5_RS09060 1949897..1950406 - 510 WP_005377035.1 GNAT family N-acetyltransferase -
K04M5_RS09065 1950552..1951034 - 483 WP_017821432.1 hypothetical protein -
K04M5_RS09070 1951185..1951673 - 489 WP_054730711.1 DUF523 domain-containing protein -
K04M5_RS09075 1951712..1951804 - 93 WP_197687490.1 DUF3265 domain-containing protein -
K04M5_RS09080 1951834..1952304 - 471 WP_054730714.1 GNAT family N-acetyltransferase -
K04M5_RS09085 1952354..1952446 - 93 WP_086046818.1 DUF3265 domain-containing protein -
K04M5_RS09090 1952482..1952784 - 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K04M5_RS09095 1952772..1953029 - 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K04M5_RS09100 1953233..1953790 - 558 WP_054730719.1 hypothetical protein -
K04M5_RS09105 1953905..1954156 - 252 WP_054730722.1 hypothetical protein -
K04M5_RS26705 1954170..1954400 - 231 WP_157664342.1 hypothetical protein -
K04M5_RS09110 1954436..1954528 - 93 WP_080256086.1 DUF3265 domain-containing protein -
K04M5_RS09115 1954562..1954978 - 417 WP_033907128.1 DUF1311 domain-containing protein -
K04M5_RS09120 1955008..1955100 - 93 WP_079858050.1 DUF3265 domain-containing protein -
K04M5_RS09125 1955126..1955473 - 348 WP_005448158.1 nucleic acid-binding protein -
K04M5_RS09130 1955501..1955611 - 111 WP_085570176.1 DUF3265 domain-containing protein -
K04M5_RS09135 1955619..1955963 - 345 WP_054730730.1 antibiotic biosynthesis monooxygenase -
K04M5_RS09140 1956088..1956180 - 93 WP_078535132.1 DUF3265 domain-containing protein -
K04M5_RS09145 1956213..1956479 - 267 WP_054730732.1 hypothetical protein -
K04M5_RS09150 1956640..1957317 - 678 WP_054730736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1937039..2081187 144148
- inside Integron - - 1948787..1968333 19546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T68270 WP_005377013.1 NZ_CP017899:c1952784-1952482 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T68270 NZ_CP017899:c1952784-1952482 [Vibrio alginolyticus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATCTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATTCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT68270 WP_005377012.1 NZ_CP017899:c1953029-1952772 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT68270 NZ_CP017899:c1953029-1952772 [Vibrio alginolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCGGATCTCCACGATACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGATAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References