Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1959027..1959574 Replicon chromosome
Accession NZ_CP017896
Organism Vibrio alginolyticus isolate K04M3

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag K04M3_RS09155 Protein ID WP_005377013.1
Coordinates 1959027..1959329 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag K04M3_RS09160 Protein ID WP_005377012.1
Coordinates 1959317..1959574 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K04M3_RS09100 1954099..1954515 - 417 WP_157664637.1 hypothetical protein -
K04M3_RS09105 1954484..1955335 - 852 WP_054730937.1 IS3 family transposase -
K04M3_RS09110 1955419..1955640 - 222 Protein_1724 transposase -
K04M3_RS09115 1955831..1956307 - 477 WP_086046816.1 GNAT family N-acetyltransferase -
K04M3_RS09120 1956335..1956427 - 93 WP_005526494.1 DUF3265 domain-containing protein -
K04M3_RS09125 1956442..1956951 - 510 WP_005377035.1 GNAT family N-acetyltransferase -
K04M3_RS09130 1957097..1957579 - 483 WP_017821432.1 hypothetical protein -
K04M3_RS09135 1957730..1958218 - 489 WP_054730711.1 DUF523 domain-containing protein -
K04M3_RS09140 1958257..1958349 - 93 WP_197687490.1 DUF3265 domain-containing protein -
K04M3_RS09145 1958379..1958849 - 471 WP_054730714.1 GNAT family N-acetyltransferase -
K04M3_RS09150 1958899..1958991 - 93 WP_086046818.1 DUF3265 domain-containing protein -
K04M3_RS09155 1959027..1959329 - 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K04M3_RS09160 1959317..1959574 - 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K04M3_RS09165 1959778..1960335 - 558 WP_054730719.1 hypothetical protein -
K04M3_RS09170 1960450..1960701 - 252 WP_054730722.1 hypothetical protein -
K04M3_RS26910 1960715..1960945 - 231 WP_157664342.1 hypothetical protein -
K04M3_RS09175 1960981..1961073 - 93 WP_080256086.1 DUF3265 domain-containing protein -
K04M3_RS09180 1961107..1961523 - 417 WP_033907128.1 DUF1311 domain-containing protein -
K04M3_RS09185 1961553..1961645 - 93 WP_079858050.1 DUF3265 domain-containing protein -
K04M3_RS09190 1961671..1962018 - 348 WP_005448158.1 nucleic acid-binding protein -
K04M3_RS09195 1962046..1962156 - 111 WP_085570176.1 DUF3265 domain-containing protein -
K04M3_RS09200 1962164..1962508 - 345 WP_054730730.1 antibiotic biosynthesis monooxygenase -
K04M3_RS09205 1962633..1962725 - 93 WP_078535132.1 DUF3265 domain-containing protein -
K04M3_RS09210 1962758..1963024 - 267 WP_054730732.1 hypothetical protein -
K04M3_RS09215 1963185..1963862 - 678 WP_054730736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1955332..1974878 19546
- inside Genomic island - - 1943584..2087732 144148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T68268 WP_005377013.1 NZ_CP017896:c1959329-1959027 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T68268 NZ_CP017896:c1959329-1959027 [Vibrio alginolyticus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATCTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATTCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT68268 WP_005377012.1 NZ_CP017896:c1959574-1959317 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT68268 NZ_CP017896:c1959574-1959317 [Vibrio alginolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCGGATCTCCACGATACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGATAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References