Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1954687..1955234 Replicon chromosome
Accession NZ_CP017891
Organism Vibrio alginolyticus strain K04M1

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag K04M1_RS09225 Protein ID WP_005377013.1
Coordinates 1954687..1954989 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag K04M1_RS09230 Protein ID WP_005377012.1
Coordinates 1954977..1955234 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K04M1_RS09160 1949759..1950082 - 324 WP_086046815.1 hypothetical protein -
K04M1_RS09165 1950144..1951037 - 894 WP_107488250.1 IS3 family transposase -
K04M1_RS09170 1951079..1951300 - 222 Protein_1779 transposase -
K04M1_RS09175 1951491..1951967 - 477 WP_086046816.1 GNAT family N-acetyltransferase -
K04M1_RS09180 1951995..1952087 - 93 WP_005526494.1 DUF3265 domain-containing protein -
K04M1_RS09185 1952102..1952611 - 510 WP_005377035.1 GNAT family N-acetyltransferase -
K04M1_RS09190 1952648..1952742 - 95 Protein_1783 hypothetical protein -
K04M1_RS09195 1952757..1953239 - 483 WP_017821432.1 hypothetical protein -
K04M1_RS09200 1953258..1953347 - 90 Protein_1785 nitrate reductase -
K04M1_RS09205 1953390..1953878 - 489 WP_054730711.1 DUF523 domain-containing protein -
K04M1_RS09210 1953917..1954042 - 126 WP_086046817.1 DUF3265 domain-containing protein -
K04M1_RS09215 1954039..1954509 - 471 WP_054730714.1 GNAT family N-acetyltransferase -
K04M1_RS09220 1954559..1954651 - 93 WP_086046818.1 DUF3265 domain-containing protein -
K04M1_RS09225 1954687..1954989 - 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K04M1_RS09230 1954977..1955234 - 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K04M1_RS09235 1955438..1955995 - 558 WP_054730719.1 hypothetical protein -
K04M1_RS09240 1956110..1956361 - 252 WP_054730722.1 hypothetical protein -
K04M1_RS09245 1956641..1956733 - 93 WP_080256086.1 DUF3265 domain-containing protein -
K04M1_RS09250 1956767..1957183 - 417 WP_033907128.1 DUF1311 domain-containing protein -
K04M1_RS09255 1957213..1957305 - 93 WP_079858050.1 DUF3265 domain-containing protein -
K04M1_RS09260 1957331..1957678 - 348 WP_005448158.1 nucleic acid-binding protein -
K04M1_RS09265 1957706..1957795 - 90 WP_078558657.1 DUF3265 domain-containing protein -
K04M1_RS09270 1957824..1958168 - 345 WP_054730730.1 antibiotic biosynthesis monooxygenase -
K04M1_RS09275 1958293..1958385 - 93 WP_078535132.1 DUF3265 domain-containing protein -
K04M1_RS09280 1958418..1958684 - 267 WP_054730732.1 hypothetical protein -
K04M1_RS09285 1958845..1959522 - 678 WP_054730736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1939244..2083392 144148
- inside Integron - - 1950992..1970538 19546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T68266 WP_005377013.1 NZ_CP017891:c1954989-1954687 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T68266 NZ_CP017891:c1954989-1954687 [Vibrio alginolyticus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATCTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATTCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT68266 WP_005377012.1 NZ_CP017891:c1955234-1954977 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT68266 NZ_CP017891:c1955234-1954977 [Vibrio alginolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCGGATCTCCACGATACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGATAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References