Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1951157..1951704 Replicon chromosome
Accession NZ_CP017889
Organism Vibrio alginolyticus strain K01M1

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag K01M1_RS09195 Protein ID WP_005377013.1
Coordinates 1951157..1951459 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag K01M1_RS09200 Protein ID WP_005377012.1
Coordinates 1951447..1951704 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K01M1_RS09130 1946229..1946633 - 405 WP_157664343.1 hypothetical protein -
K01M1_RS09135 1946614..1947465 - 852 WP_054730937.1 IS3 family transposase -
K01M1_RS09140 1947549..1947770 - 222 Protein_1710 transposase -
K01M1_RS09145 1947961..1948437 - 477 WP_086046816.1 GNAT family N-acetyltransferase -
K01M1_RS09150 1948465..1948557 - 93 WP_005526494.1 DUF3265 domain-containing protein -
K01M1_RS09155 1948572..1949081 - 510 WP_005377035.1 GNAT family N-acetyltransferase -
K01M1_RS09165 1949227..1949709 - 483 WP_017821432.1 hypothetical protein -
K01M1_RS09175 1949860..1950348 - 489 WP_054730711.1 DUF523 domain-containing protein -
K01M1_RS09180 1950387..1950479 - 93 WP_197687490.1 DUF3265 domain-containing protein -
K01M1_RS09185 1950509..1950979 - 471 WP_054730714.1 GNAT family N-acetyltransferase -
K01M1_RS09190 1951029..1951121 - 93 WP_086046818.1 DUF3265 domain-containing protein -
K01M1_RS09195 1951157..1951459 - 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K01M1_RS09200 1951447..1951704 - 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K01M1_RS09205 1951908..1952465 - 558 WP_054730719.1 hypothetical protein -
K01M1_RS09210 1952580..1952831 - 252 WP_054730722.1 hypothetical protein -
K01M1_RS25275 1952845..1953075 - 231 WP_157664342.1 hypothetical protein -
K01M1_RS09215 1953111..1953203 - 93 WP_080256086.1 DUF3265 domain-containing protein -
K01M1_RS09220 1953237..1953653 - 417 WP_033907128.1 DUF1311 domain-containing protein -
K01M1_RS09225 1953683..1953775 - 93 WP_079858050.1 DUF3265 domain-containing protein -
K01M1_RS09230 1953801..1954148 - 348 WP_005448158.1 nucleic acid-binding protein -
K01M1_RS09235 1954176..1954286 - 111 WP_085570176.1 DUF3265 domain-containing protein -
K01M1_RS09240 1954294..1954638 - 345 WP_054730730.1 antibiotic biosynthesis monooxygenase -
K01M1_RS09245 1954763..1954855 - 93 WP_078535132.1 DUF3265 domain-containing protein -
K01M1_RS09250 1954888..1955154 - 267 WP_054730732.1 hypothetical protein -
K01M1_RS09255 1955315..1955992 - 678 WP_054730736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1935714..2079862 144148
- inside Integron - - 1947462..1967008 19546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T68265 WP_005377013.1 NZ_CP017889:c1951459-1951157 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T68265 NZ_CP017889:c1951459-1951157 [Vibrio alginolyticus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATCTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATTCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT68265 WP_005377012.1 NZ_CP017889:c1951704-1951447 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT68265 NZ_CP017889:c1951704-1951447 [Vibrio alginolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCGGATCTCCACGATACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGATAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References