Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 4540089..4540678 Replicon chromosome
Accession NZ_CP017886
Organism Pseudomonas frederiksbergensis strain ERDD5:01

Toxin (Protein)


Gene name hicA Uniprot ID A0A1J0EQ62
Locus tag BLL42_RS21775 Protein ID WP_071554068.1
Coordinates 4540089..4540337 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1J0EQD4
Locus tag BLL42_RS21780 Protein ID WP_071554070.1
Coordinates 4540337..4540678 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLL42_RS21740 4535309..4536430 - 1122 WP_071555815.1 hypothetical protein -
BLL42_RS21745 4536578..4536811 - 234 WP_071554059.1 hypothetical protein -
BLL42_RS21750 4536808..4537041 - 234 WP_071554060.1 hypothetical protein -
BLL42_RS21755 4537047..4537295 - 249 WP_071555816.1 hypothetical protein -
BLL42_RS21760 4537882..4538661 - 780 WP_071554062.1 hypothetical protein -
BLL42_RS21765 4538738..4539121 - 384 WP_071554064.1 helix-turn-helix transcriptional regulator -
BLL42_RS21770 4539689..4539937 - 249 WP_071554066.1 DUF1654 domain-containing protein -
BLL42_RS21775 4540089..4540337 + 249 WP_071554068.1 type II toxin-antitoxin system HicA family toxin Toxin
BLL42_RS21780 4540337..4540678 + 342 WP_071554070.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BLL42_RS21785 4540789..4541028 - 240 WP_071554072.1 hypothetical protein -
BLL42_RS29300 4541316..4541504 + 189 WP_081427319.1 hypothetical protein -
BLL42_RS21795 4541499..4542299 - 801 WP_071554074.1 helix-turn-helix domain-containing protein -
BLL42_RS21800 4542416..4542613 + 198 WP_071555818.1 helix-turn-helix domain-containing protein -
BLL42_RS21805 4542769..4543581 + 813 WP_071554075.1 phage regulatory protein/antirepressor Ant -
BLL42_RS21810 4543578..4543910 + 333 WP_071554076.1 hypothetical protein -
BLL42_RS21815 4543907..4544695 + 789 WP_081427320.1 hypothetical protein -
BLL42_RS21820 4544731..4545444 + 714 WP_071555819.1 Replication protein P -
BLL42_RS21825 4545437..4545655 + 219 WP_071554078.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4522754..4573298 50544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9227.70 Da        Isoelectric Point: 10.0543

>T68263 WP_071554068.1 NZ_CP017886:4540089-4540337 [Pseudomonas frederiksbergensis]
MSKQEKLLAKLLNKQSGFTWQELVSLLKGLGFSQIEGDGSRVKFSNDDPQAMINLHKPHPGNELKAYVKRQVIEHLKAEG
LI

Download         Length: 249 bp

>T68263 NZ_CP017886:4540089-4540337 [Pseudomonas frederiksbergensis]
ATGTCCAAGCAAGAAAAGCTGCTAGCCAAGCTACTGAACAAGCAATCCGGGTTCACTTGGCAGGAATTGGTCTCGCTGTT
AAAGGGCCTCGGATTTAGCCAGATCGAGGGTGACGGCAGTCGAGTGAAATTCAGCAACGACGATCCGCAGGCAATGATCA
ACCTGCACAAGCCGCACCCCGGTAACGAACTGAAGGCCTACGTCAAGCGTCAGGTTATTGAGCACCTGAAGGCAGAAGGA
TTGATTTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12516.03 Da        Isoelectric Point: 5.8845

>AT68263 WP_071554070.1 NZ_CP017886:4540337-4540678 [Pseudomonas frederiksbergensis]
MSTMLQHRGYYGSIEASPEDNCLFGKLQFIRALVSYEGETVAELTQAFRAAVDDYLNTCTSLSQEPEVPCKGSFNVRIGH
DLHLAASVAATRHSISLNDLTRKALSEYLEHHA

Download         Length: 342 bp

>AT68263 NZ_CP017886:4540337-4540678 [Pseudomonas frederiksbergensis]
ATGAGTACCATGCTGCAGCACCGAGGCTATTACGGATCCATTGAGGCCAGTCCCGAGGACAATTGCCTGTTCGGCAAGCT
TCAATTCATCCGCGCGCTGGTGAGCTATGAGGGGGAGACGGTAGCCGAGCTGACTCAGGCATTCCGCGCCGCAGTGGATG
ATTATCTCAACACCTGCACTTCTCTGAGCCAAGAACCTGAGGTCCCGTGCAAGGGATCGTTCAACGTAAGGATAGGGCAC
GACCTGCACCTGGCCGCGAGCGTGGCCGCGACCCGCCATAGTATTTCCCTGAACGATCTGACTCGGAAGGCTCTGAGCGA
GTACCTGGAGCATCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0EQ62

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0EQD4

References