Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2676052..2676743 Replicon chromosome
Accession NZ_CP017886
Organism Pseudomonas frederiksbergensis strain ERDD5:01

Toxin (Protein)


Gene name hicA Uniprot ID A0A1J0ETX6
Locus tag BLL42_RS13000 Protein ID WP_071555753.1
Coordinates 2676561..2676743 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1J0EL57
Locus tag BLL42_RS12995 Protein ID WP_071552457.1
Coordinates 2676052..2676468 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLL42_RS12970 2671226..2672203 + 978 WP_071555752.1 taurine ABC transporter substrate-binding protein -
BLL42_RS12975 2672219..2673013 + 795 WP_071552453.1 taurine ABC transporter ATP-binding subunit -
BLL42_RS12980 2673010..2673849 + 840 WP_071552454.1 taurine ABC transporter permease TauC -
BLL42_RS12985 2673909..2674745 + 837 WP_071552455.1 taurine dioxygenase -
BLL42_RS12990 2674837..2675874 - 1038 WP_071552456.1 L-glyceraldehyde 3-phosphate reductase -
BLL42_RS12995 2676052..2676468 - 417 WP_071552457.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BLL42_RS13000 2676561..2676743 - 183 WP_071555753.1 type II toxin-antitoxin system HicA family toxin Toxin
BLL42_RS13005 2676874..2677764 - 891 WP_071552458.1 LysR family transcriptional regulator -
BLL42_RS13010 2677894..2678634 + 741 WP_071552459.1 SDR family oxidoreductase -
BLL42_RS13015 2678704..2678961 + 258 WP_071552460.1 hypothetical protein -
BLL42_RS13020 2678978..2680939 - 1962 WP_167368562.1 choline transporter BetT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6900.02 Da        Isoelectric Point: 10.7459

>T68261 WP_071555753.1 NZ_CP017886:c2676743-2676561 [Pseudomonas frederiksbergensis]
MRSREMIRMIEEDGWYLVAVKGSHHQYKHSRKSGRVTIKHPDADLPKGTINSILKQAGLK

Download         Length: 183 bp

>T68261 NZ_CP017886:c2676743-2676561 [Pseudomonas frederiksbergensis]
ATGCGTAGTCGGGAAATGATCAGGATGATCGAAGAGGACGGTTGGTATTTGGTGGCGGTCAAAGGTAGCCACCATCAATA
CAAACATTCGCGCAAATCAGGGAGGGTAACCATCAAGCATCCTGATGCGGATCTGCCAAAAGGAACAATCAACAGCATTT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15115.94 Da        Isoelectric Point: 4.3560

>AT68261 WP_071552457.1 NZ_CP017886:c2676468-2676052 [Pseudomonas frederiksbergensis]
MKFPVVLHKDADSEYGVIIPDVAGCFSAGGTVAQALENVKEALALHYEGLVTDGDPLPQVREIDEHLENPDYAGGVWAVV
EFDVTPYFGKSVRFNATLPEQLLERIDQTVKRDQRYSSRSGFLAAAALRELSAEYGVS

Download         Length: 417 bp

>AT68261 NZ_CP017886:c2676468-2676052 [Pseudomonas frederiksbergensis]
ATGAAATTCCCAGTCGTTCTGCATAAGGATGCTGATTCAGAGTACGGAGTAATTATCCCCGACGTTGCGGGTTGTTTCTC
TGCAGGTGGAACGGTGGCGCAGGCGCTCGAAAACGTTAAAGAAGCGCTGGCGTTGCATTACGAGGGACTTGTCACCGATG
GCGATCCGTTGCCGCAGGTTCGCGAGATCGATGAACACCTCGAGAACCCTGATTACGCGGGTGGTGTTTGGGCGGTGGTC
GAGTTTGACGTGACACCTTATTTCGGCAAGTCCGTGCGTTTCAACGCCACACTGCCGGAGCAGTTGCTGGAGCGAATCGA
CCAGACCGTGAAGCGCGATCAGCGCTACAGTTCGCGCTCCGGTTTTCTCGCCGCCGCCGCATTACGCGAATTGTCGGCTG
AGTACGGCGTTTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0ETX6

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0EL57

References