Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2604412..2605049 Replicon chromosome
Accession NZ_CP017886
Organism Pseudomonas frederiksbergensis strain ERDD5:01

Toxin (Protein)


Gene name vapC Uniprot ID A0A1J0EK94
Locus tag BLL42_RS12605 Protein ID WP_071552388.1
Coordinates 2604642..2605049 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1J0EKV4
Locus tag BLL42_RS12600 Protein ID WP_054595147.1
Coordinates 2604412..2604642 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLL42_RS12570 2599510..2600592 + 1083 WP_071552382.1 hypothetical protein -
BLL42_RS12575 2600711..2601502 + 792 WP_071552383.1 TSUP family transporter -
BLL42_RS12580 2601643..2602098 - 456 WP_071552384.1 hypothetical protein -
BLL42_RS12585 2602343..2603308 + 966 WP_071552385.1 alpha/beta fold hydrolase -
BLL42_RS12590 2603346..2603762 + 417 WP_071552386.1 hypothetical protein -
BLL42_RS12595 2603769..2604221 + 453 WP_071552387.1 hypothetical protein -
BLL42_RS12600 2604412..2604642 + 231 WP_054595147.1 antitoxin Antitoxin
BLL42_RS12605 2604642..2605049 + 408 WP_071552388.1 tRNA(fMet)-specific endonuclease VapC Toxin
BLL42_RS12610 2605121..2606512 - 1392 WP_071552389.1 GABA permease -
BLL42_RS12615 2607067..2607840 + 774 WP_071552390.1 ABC transporter ATP-binding protein -
BLL42_RS12620 2607854..2608609 + 756 WP_071552391.1 ABC transporter substrate-binding protein -
BLL42_RS12625 2608690..2609385 + 696 WP_071552392.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15058.43 Da        Isoelectric Point: 6.7508

>T68259 WP_071552388.1 NZ_CP017886:2604642-2605049 [Pseudomonas frederiksbergensis]
MIKYMLDTNICIFTIKNKPQVVRDAFNRHHGQLCISAVTLMELIYGAEKSAAPEKNLAVIEGFAARLEVLPFDYEAAAHT
GMIRSELAKAGTPIGPYDHMIAGHARSQGFIVVTNNLRELERVPGLRVEDWVHLD

Download         Length: 408 bp

>T68259 NZ_CP017886:2604642-2605049 [Pseudomonas frederiksbergensis]
ATGATCAAATACATGCTCGACACCAACATCTGCATTTTCACCATCAAGAACAAACCGCAGGTCGTGCGAGACGCGTTCAA
TCGCCATCACGGCCAGTTGTGCATCAGCGCAGTCACGCTGATGGAATTGATTTACGGCGCTGAAAAATCAGCGGCACCGG
AAAAGAACCTGGCCGTCATCGAGGGCTTTGCGGCTCGTCTTGAAGTCCTTCCCTTCGACTACGAAGCCGCTGCCCACACC
GGAATGATCCGCTCGGAACTTGCAAAAGCAGGAACACCAATAGGCCCTTACGATCACATGATTGCGGGTCACGCGCGCTC
ACAGGGGTTCATTGTGGTGACGAATAATCTTCGGGAGCTTGAGCGTGTTCCCGGATTGCGTGTAGAGGACTGGGTACACC
TCGATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8629.63 Da        Isoelectric Point: 4.2683

>AT68259 WP_054595147.1 NZ_CP017886:2604412-2604642 [Pseudomonas frederiksbergensis]
MEQTTLFMSNRSQAVRLPKAVAMPEDVKRVNVVAIGRARIITPADEAWDSWFDGDNVTADFMADREQPADQERESF

Download         Length: 231 bp

>AT68259 NZ_CP017886:2604412-2604642 [Pseudomonas frederiksbergensis]
ATGGAACAGACCACCCTTTTCATGAGTAATCGAAGCCAGGCTGTCCGCTTGCCCAAAGCAGTGGCAATGCCTGAAGACGT
GAAACGCGTCAATGTTGTAGCCATTGGTCGAGCTCGTATCATCACTCCGGCAGATGAAGCCTGGGATAGCTGGTTCGATG
GCGATAACGTCACTGCCGATTTCATGGCCGACCGTGAGCAACCGGCCGATCAGGAGCGCGAGTCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0EK94

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0EKV4

References