68255

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1218987..1220026 Replicon chromosome
Accession NZ_CP017886
Organism Pseudomonas frederiksbergensis strain ERDD5:01

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A1J0EGQ0
Locus tag BLL42_RS06130 Protein ID WP_071551245.1
Coordinates 1219451..1220026 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A1J0EGX5
Locus tag BLL42_RS06125 Protein ID WP_071551244.1
Coordinates 1218987..1219454 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLL42_RS06100 1215022..1215942 + 921 WP_071551241.1 urea transporter -
BLL42_RS06105 1215964..1216788 + 825 WP_071551242.1 ion transporter -
BLL42_RS06110 1216878..1217876 + 999 WP_071551243.1 sulfate ABC transporter substrate-binding protein -
BLL42_RS06115 1217938..1218567 - 630 WP_174553326.1 hypothetical protein -
BLL42_RS06120 1218701..1218832 - 132 Protein_1192 type II toxin-antitoxin system HicB family antitoxin -
BLL42_RS06125 1218987..1219454 + 468 WP_071551244.1 helix-turn-helix domain-containing protein Antitoxin
BLL42_RS06130 1219451..1220026 + 576 WP_071551245.1 PIN domain-containing protein Toxin
BLL42_RS06135 1220081..1220488 - 408 WP_071551246.1 hypothetical protein -
BLL42_RS06140 1220503..1221711 - 1209 WP_071551247.1 c-type cytochrome biogenesis protein CcmI -
BLL42_RS06145 1221704..1222177 - 474 WP_071551248.1 cytochrome c-type biogenesis protein CcmH -
BLL42_RS06150 1222174..1222710 - 537 WP_071551249.1 DsbE family thiol:disulfide interchange protein -
BLL42_RS06155 1222707..1224695 - 1989 WP_071551250.1 heme lyase CcmF/NrfE family subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

SinI-like, DNA-binding domain

(84-129)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21918.20 Da        Isoelectric Point: 6.4820

>T68255 WP_071551245.1 NZ_CP017886:1219451-1220026 [Pseudomonas frederiksbergensis]
VRHSSFTVVYDACVLYPAPLRDFLMWLALSGRFRARWTLEIHNEWKRNLLKNRPDLTPEQLDRTSDLMNRAIPDACVTGY
ENLIEGLSLPDVNDRHVLAAAIRCNASVIVTFNQKDFPTRKLDPFGIEAQHPDEFIDNLFDLDPAAVIASAQRQRQQLKM
PPMNIDTYLDLLLRQGLVQSVKALTEYRAIL

Download         Length: 576 bp

>T68255 NZ_CP017886:1219451-1220026 [Pseudomonas frederiksbergensis]
GTGAGGCATTCCTCTTTTACCGTTGTATACGATGCTTGTGTTCTTTACCCCGCCCCCCTACGCGACTTTCTGATGTGGCT
CGCACTTTCCGGACGGTTTCGAGCGAGATGGACGCTGGAGATACACAACGAGTGGAAAAGGAATCTTCTGAAAAACCGTC
CTGATCTGACGCCAGAACAATTGGATCGCACATCCGACCTGATGAATCGGGCCATACCCGACGCCTGCGTGACCGGCTAC
GAAAACCTGATCGAAGGACTTTCGCTGCCGGATGTCAATGATCGTCATGTCCTGGCTGCCGCCATACGCTGTAATGCCAG
CGTCATCGTGACCTTCAATCAAAAAGACTTCCCCACCAGAAAGCTCGACCCCTTTGGCATCGAAGCCCAGCACCCCGACG
AATTTATCGATAACCTTTTCGACCTGGATCCTGCGGCGGTTATTGCGTCAGCCCAACGGCAGCGCCAGCAACTGAAAATG
CCACCAATGAATATCGATACCTACCTGGATTTGCTGCTGCGCCAAGGCCTGGTGCAGTCGGTAAAGGCGTTGACCGAATA
CCGAGCCATTCTTTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17293.79 Da        Isoelectric Point: 6.3375

>AT68255 WP_071551244.1 NZ_CP017886:1218987-1219454 [Pseudomonas frederiksbergensis]
MSTVTRPPINLPMEREVQAAIEGQRALAGYLATRFDTQRIQIFDEQNEAHSVELPTSALRLLVDILAELAAGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESGELSYHKTGKHRRVRFAELMDYKCKRDAASEQAMALLAEQAQALRFGYE

Download         Length: 468 bp

>AT68255 NZ_CP017886:1218987-1219454 [Pseudomonas frederiksbergensis]
ATGTCGACCGTCACTCGTCCCCCGATCAATCTACCCATGGAGCGTGAGGTACAGGCCGCCATCGAAGGTCAGCGCGCCTT
GGCAGGCTATCTCGCTACTCGGTTCGACACTCAGCGGATTCAGATTTTCGATGAGCAGAATGAAGCTCACAGTGTCGAAC
TCCCGACTTCGGCCCTGCGGTTGCTTGTCGATATCCTGGCAGAGCTGGCAGCGGGCAATGCGGTCAAAGTAGTGCCGGTC
CACGCAGAACTCACCACGCAAGAAGCCGCCGACCTGCTCAACGTCTCACGCCCACACCTGATCAAACTGCTGGAATCCGG
GGAACTGTCCTACCACAAAACCGGCAAGCACCGGCGTGTGCGTTTTGCCGAATTGATGGACTATAAATGCAAGCGCGATG
CAGCCAGTGAGCAAGCAATGGCATTACTCGCAGAACAGGCACAGGCGTTGAGGTTCGGATACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0EGQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0EGX5

References