Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 191..1109 Replicon plasmid pCCDM33S
Accession NZ_CP017874
Organism Campylobacter coli strain WA333

Toxin (Protein)


Gene name Fic Uniprot ID A0A3Z8EYW1
Locus tag BLD33_RS09685 Protein ID WP_002790624.1
Coordinates 191..874 (-) Length 228 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID A0A0Q2TTN4
Locus tag BLD33_RS09690 Protein ID WP_002804094.1
Coordinates 867..1109 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLD33_RS09685 191..874 - 684 WP_002790624.1 Fic family protein Toxin
BLD33_RS09690 867..1109 - 243 WP_002804094.1 hypothetical protein Antitoxin
BLD33_RS09695 1200..1919 - 720 WP_057031750.1 conjugal transfer protein TraL -
BLD33_RS09700 1930..3753 - 1824 WP_057031751.1 type IV secretory system conjugative DNA transfer family protein -
BLD33_RS09705 3750..5963 - 2214 WP_052778217.1 DUF1738 domain-containing protein -
BLD33_RS10240 5968..6108 - 141 WP_002779802.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..25058 25058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(60-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 228 a.a.        Molecular weight: 25802.76 Da        Isoelectric Point: 10.0206

>T68246 WP_002790624.1 NZ_CP017874:c874-191 [Campylobacter coli]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKKERIITLQAAKKLELNPIKGNFDYQHLKDIHKALFKDVYTWA
GKDRMEVGLHGNFGKYAPNGTITNFVPGKDLNVTAQQIFTWLKEDNYLTNSKDLNDFAKNLAEFARNLNALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLIPKDKMIMASVEASQLKLGKLEAIIKTNLKSFRQNLDLEQNKGISL

Download         Length: 684 bp

>T68246 NZ_CP017874:c874-191 [Campylobacter coli]
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGATAGACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAAAAAGAAAGAATAATAACTCTACAAGCCGCTAAAAAATTAGAGCTTA
ATCCAATTAAAGGCAATTTTGACTATCAACACTTAAAAGATATACATAAAGCACTTTTTAAAGATGTTTATACTTGGGCT
GGAAAAGATAGAATGGAAGTAGGTTTGCATGGAAATTTTGGAAAATATGCACCAAATGGAACAATTACTAATTTTGTTCC
TGGAAAAGATTTAAATGTAACCGCTCAACAAATTTTTACTTGGCTTAAAGAAGACAATTACTTAACAAATTCAAAAGATC
TTAACGATTTTGCAAAGAACTTAGCCGAATTTGCTAGAAACCTAAATGCTTTGCACCCCTTTAGAGAAGGTAACGGCAGA
ACTCAAAGAATATTTTTAAATGAATTGGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATACCAAAAGATAAAAT
GATAATGGCATCTGTAGAAGCTTCACAATTGAAATTAGGAAAACTTGAAGCCATAATAAAAACAAATCTAAAAAGCTTTA
GACAAAACTTAGATTTAGAGCAAAATAAAGGAATATCATTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9452.68 Da        Isoelectric Point: 4.3535

>AT68246 WP_002804094.1 NZ_CP017874:c1109-867 [Campylobacter coli]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEQNKSIICGFAIENMFANEEDIINLIKVDKQEKTPDEIIAEYKKEWGVND

Download         Length: 243 bp

>AT68246 NZ_CP017874:c1109-867 [Campylobacter coli]
ATGCAAAAACAATATCCCGAAGTGCATAGCTTAGAAGAAAGCCTTGCGATACTTAAAAAATATAAAGATGATTTAACTAA
AGAGCAATATGAGCAAAATAAATCTATTATTTGTGGATTTGCTATTGAGAATATGTTTGCAAATGAAGAAGACATTATAA
ATCTCATAAAAGTAGATAAACAAGAAAAAACACCTGATGAAATAATCGCCGAATATAAAAAAGAGTGGGGTGTAAATGAT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z8EYW1

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q2TTN4

References