Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 18074..18975 Replicon plasmid pCCDM105S
Accession NZ_CP017867
Organism Campylobacter coli strain YF2105

Toxin (Protein)


Gene name Fic Uniprot ID A0A3Z8TY88
Locus tag BLD35_RS09290 Protein ID WP_002814355.1
Coordinates 18074..18736 (-) Length 221 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID C5F2H5
Locus tag BLD35_RS09295 Protein ID WP_002814351.1
Coordinates 18736..18975 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLD35_RS09255 13394..13777 + 384 WP_004288751.1 DNA transfer protein -
BLD35_RS09260 13740..15896 + 2157 WP_057990995.1 relaxase/mobilization nuclease domain-containing protein -
BLD35_RS09270 16137..16361 - 225 WP_002790621.1 hypothetical protein -
BLD35_RS09275 16364..17050 - 687 WP_002791558.1 AAA family ATPase -
BLD35_RS09280 17142..17537 - 396 WP_002782959.1 conjugal transfer protein TraM -
BLD35_RS09285 17602..18069 - 468 WP_002782960.1 signal peptidase I -
BLD35_RS09290 18074..18736 - 663 WP_002814355.1 Fic family protein Toxin
BLD35_RS09295 18736..18975 - 240 WP_002814351.1 hypothetical protein Antitoxin
BLD35_RS09300 19078..19797 - 720 WP_002844665.1 conjugal transfer protein TraL -
BLD35_RS09305 19808..21631 - 1824 WP_057031751.1 type IV secretory system conjugative DNA transfer family protein -
BLD35_RS09310 21628..23841 - 2214 WP_002790336.1 DUF1738 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..25284 25284


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(53-162)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 221 a.a.        Molecular weight: 25478.46 Da        Isoelectric Point: 10.1005

>T68245 WP_002814355.1 NZ_CP017867:c18736-18074 [Campylobacter coli]
MWDSQENLSEFDKFLIKTNKIGAKSLDELFRKERMITNKKALELGKNPIKGNFDYQHLKDIHKALFEDVYTWAGQDRMQM
GLKEKFAKYAPNGAIINFVPGKELDKYSKIIFDELAKNNYLKNSKDLNHFAKNLAKFMGEINALHPFREGNGRTQRIFLN
ELAKNAGYKLDLNLISKHKMIHACVEASQLKPGRLEALIKDNLKNFRQNLDLEQNKGMSL

Download         Length: 663 bp

>T68245 NZ_CP017867:c18736-18074 [Campylobacter coli]
ATGTGGGATTCTCAAGAAAATTTATCAGAGTTTGATAAATTTTTAATCAAGACTAATAAAATAGGTGCAAAATCATTAGA
TGAATTGTTTCGCAAAGAAAGAATGATAACAAACAAAAAAGCCTTAGAATTAGGCAAAAATCCCATTAAAGGCAATTTTG
ATTATCAGCATTTAAAAGATATACATAAAGCACTTTTTGAAGATGTTTATACTTGGGCGGGACAAGATAGAATGCAAATG
GGGCTAAAAGAAAAATTTGCAAAATATGCACCCAATGGAGCAATTATTAATTTTGTTCCTGGAAAAGAGTTAGATAAATA
CTCTAAAATAATTTTTGATGAACTTGCAAAAAATAATTATCTAAAAAACTCCAAAGATCTAAATCATTTTGCAAAAAATT
TAGCAAAATTTATGGGCGAAATCAATGCTTTACACCCTTTTAGAGAAGGTAACGGCAGAACTCAAAGAATATTTTTAAAT
GAATTAGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATTTCTAAGCATAAAATGATACATGCTTGCGTAGAAGC
TTCACAATTAAAACCTGGAAGATTGGAGGCTTTAATTAAAGACAATCTAAAAAACTTTAGACAAAATTTAGATTTGGAGC
AAAATAAAGGAATGTCGTTATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9089.40 Da        Isoelectric Point: 4.6535

>AT68245 WP_002814351.1 NZ_CP017867:c18975-18736 [Campylobacter coli]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEAIRSNIGNFAIEDMFLNEKDIIDNVKIIKGEATANECIVALKKEWGVS

Download         Length: 240 bp

>AT68245 NZ_CP017867:c18975-18736 [Campylobacter coli]
ATGCAAAAACAATATCCCGAAGTGCATAGCTTAGAAGAAAGCCTTGCGATACTTAAAAAATATAAAGATGATTTGACTAA
AGAGCAATACGAAGCCATAAGATCAAATATAGGTAATTTTGCAATAGAAGATATGTTTTTGAATGAAAAAGATATTATTG
ATAATGTTAAAATTATAAAAGGCGAAGCAACAGCTAATGAATGTATTGTTGCATTAAAGAAAGAATGGGGAGTGTCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z8TY88

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z9DV79

References