Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1350836..1351671 Replicon chromosome
Accession NZ_CP017844
Organism Escherichia coli strain FMU073332

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag BLJ80_RS07330 Protein ID WP_000854743.1
Coordinates 1350836..1351213 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag BLJ80_RS07335 Protein ID WP_001285298.1
Coordinates 1351303..1351671 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLJ80_RS07300 1346193..1347116 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
BLJ80_RS07305 1347227..1348411 - 1185 WP_001172882.1 sugar efflux transporter -
BLJ80_RS07315 1349207..1350045 - 839 Protein_1257 DUF4942 domain-containing protein -
BLJ80_RS07320 1350142..1350339 - 198 WP_000839275.1 DUF957 domain-containing protein -
BLJ80_RS07325 1350351..1350839 - 489 WP_000761693.1 hypothetical protein -
BLJ80_RS07330 1350836..1351213 - 378 WP_000854743.1 TA system toxin CbtA family protein Toxin
BLJ80_RS07335 1351303..1351671 - 369 WP_001285298.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BLJ80_RS07340 1351721..1352365 - 645 WP_000086754.1 hypothetical protein -
BLJ80_RS07345 1352384..1352605 - 222 WP_000692295.1 DUF987 domain-containing protein -
BLJ80_RS07350 1352674..1353150 - 477 WP_032328266.1 RadC family protein -
BLJ80_RS07355 1353165..1353650 - 486 WP_000206660.1 antirestriction protein -
BLJ80_RS07360 1353742..1354563 - 822 WP_001706654.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14172.08 Da        Isoelectric Point: 6.8519

>T68195 WP_000854743.1 NZ_CP017844:c1351213-1350836 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDSVNFLVEKYALVRTDQPGF
GACTYSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T68195 NZ_CP017844:c1351213-1350836 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATTCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
GGTGCCTGTACCTATTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13710.44 Da        Isoelectric Point: 5.8799

>AT68195 WP_001285298.1 NZ_CP017844:c1351671-1351303 [Escherichia coli]
MSDSRHETNYPDDHNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKN

Download         Length: 369 bp

>AT68195 NZ_CP017844:c1351671-1351303 [Escherichia coli]
ATGTCAGACTCGCGCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAT
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References