Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1734065..1734600 Replicon chromosome
Accession NZ_CP017811
Organism Haemophilus influenzae strain NML-Hia-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BG256_RS08455 Protein ID WP_071163272.1
Coordinates 1734337..1734600 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BG256_RS08450 Protein ID WP_071163271.1
Coordinates 1734065..1734340 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG256_RS08430 1729469..1731508 - 2040 WP_071163269.1 excinuclease ABC subunit B -
BG256_RS08440 1732123..1733091 - 969 WP_071163270.1 zinc transporter permease subunit ZevB -
BG256_RS08445 1733094..1733714 - 621 WP_005650213.1 zinc transporter binding subunit ZevA -
BG256_RS08450 1734065..1734340 + 276 WP_071163271.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG256_RS08455 1734337..1734600 + 264 WP_071163272.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG256_RS08460 1734684..1736354 + 1671 WP_005650218.1 energy-dependent translational throttle protein EttA -
BG256_RS08465 1736417..1736758 + 342 WP_040033872.1 SirB2 family protein -
BG256_RS08470 1736763..1738733 + 1971 WP_071163273.1 tRNA(Met) cytidine acetyltransferase TmcA -
BG256_RS09340 1738730..1738903 + 174 WP_005657572.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10201.90 Da        Isoelectric Point: 7.8978

>T68189 WP_071163272.1 NZ_CP017811:1734337-1734600 [Haemophilus influenzae]
MISVSGEYKREFKKHIPLLINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKVVGDEIRLARLN
THSEIFG

Download         Length: 264 bp

>T68189 NZ_CP017811:1734337-1734600 [Haemophilus influenzae]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTCTTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCATGCTTTAACTGGAAATTGGAAAGGTT
GGAGAGATTGCCATATAAAGAATGATCTTGTGCTTATTTATAAAGTGGTGGGAGATGAAATAAGGCTGGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10277.84 Da        Isoelectric Point: 6.0646

>AT68189 WP_071163271.1 NZ_CP017811:1734065-1734340 [Haemophilus influenzae]
MAAVSFRVPDETKNMAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp

>AT68189 NZ_CP017811:1734065-1734340 [Haemophilus influenzae]
ATGGCTGCAGTTAGTTTTCGAGTACCTGATGAAACTAAAAATATGGCGTTTGAAGTGATTAAAAGTTACGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCACTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTAGATAATCATCATGGGCATGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTAGCGGAGATGAAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References