Detailed information of TA system TA068188

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1116148..1116752
• Replicon: chromosome
• Accession: NZ_CP017811
• Organism: Haemophilus influenzae strain NML-Hia-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8I2W3E0
• Locus tag: BG256_RS05515
• Protein ID: WP_038440394.1
• Coordinates: 1116444..1116752 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0Y7JSS2
• Locus tag: BG256_RS05510
• Protein ID: WP_005661259.1
• Coordinates: 1116148..1116444 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG256_RS05495	1112678..1114063	+	1386	WP_071162996.1	L-seryl-tRNA(Sec) selenium transferase	-
BG256_RS05500	1114060..1115919	+	1860	WP_071162997.1	selenocysteine-specific translation elongation factor	-
BG256_RS05505	1115903..1116028	+	126	WP_005654327.1	hypothetical protein	-
BG256_RS05510	1116148..1116444	+	297	WP_005661259.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BG256_RS05515	1116444..1116752	+	309	WP_038440394.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
BG256_RS05520	1116809..1120045	-	3237	WP_071162998.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
BG256_RS05525	1120349..1121647	+	1299	WP_015701821.1	trigger factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (8-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11885.59 Da
• Isoelectric Point: 7.3189

>T68188 WP_038440394.1 NZ_CP017811:1116444-1116752 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLSLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T68188 NZ_CP017811:1116444-1116752 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTATCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11015.37 Da
• Isoelectric Point: 4.4297

>AT68188 WP_005661259.1 NZ_CP017811:1116148-1116444 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT68188 NZ_CP017811:1116148-1116444 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0Y7JSS2