Detailed information of TA system TA068186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1057561..1058032
• Replicon: chromosome
• Accession: NZ_CP017811
• Organism: Haemophilus influenzae strain NML-Hia-1

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: BG256_RS05235
• Protein ID: WP_005654546.1
• Coordinates: 1057850..1058032 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: BG256_RS05230
• Protein ID: WP_005650837.1
• Coordinates: 1057561..1057857 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG256_RS05205	1052989..1053546	-	558	WP_071162974.1	DNA-3-methyladenine glycosylase I	-
BG256_RS05210	1053543..1054361	-	819	WP_071162975.1	shikimate dehydrogenase	-
BG256_RS05215	1054365..1054916	-	552	WP_071162976.1	Sua5/YciO/YrdC/YwlC family protein	-
BG256_RS05220	1054932..1055468	-	537	WP_071162977.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
BG256_RS05225	1055478..1057394	-	1917	WP_071162978.1	ABC transporter ATP-binding protein	-
BG256_RS05230	1057561..1057857	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
BG256_RS05235	1057850..1058032	-	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
BG256_RS05240	1058293..1061252	-	2960	Protein_988	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T68186 WP_005654546.1 NZ_CP017811:c1058032-1057850 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T68186 NZ_CP017811:c1058032-1057850 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCTCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACTGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT68186 WP_005650837.1 NZ_CP017811:c1057857-1057561 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT68186 NZ_CP017811:c1057857-1057561 [Haemophilus influenzae]
ATGAATAAAATTAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTACGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9