68185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 865447..865784 Replicon chromosome
Accession NZ_CP017811
Organism Haemophilus influenzae strain NML-Hia-1

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag BG256_RS04250 Protein ID WP_071162882.1
Coordinates 865447..865584 (-) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag BG256_RS04255 Protein ID WP_005649350.1
Coordinates 865593..865784 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG256_RS04230 860638..862308 - 1671 WP_071162879.1 fructose-specific PTS transporter subunit EIIC -
BG256_RS04235 862310..863251 - 942 WP_071162880.1 1-phosphofructokinase -
BG256_RS04240 863253..864752 - 1500 WP_071162881.1 fused PTS fructose transporter subunit IIA/HPr protein -
BG256_RS04245 864824..865354 - 531 WP_005686915.1 hypothetical protein -
BG256_RS04250 865447..865584 - 138 WP_071162882.1 virulence-associated protein D Toxin
BG256_RS04255 865593..865784 - 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
BG256_RS04260 865855..867153 - 1299 Protein_806 HlyC/CorC family transporter -
BG256_RS04265 867204..867728 - 525 WP_005652096.1 DUF1523 family protein -
BG256_RS04270 867755..868537 - 783 WP_071162883.1 YchF/TatD family DNA exonuclease -
BG256_RS04275 868592..869575 - 984 WP_071162884.1 DNA polymerase III subunit delta' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5270.90 Da        Isoelectric Point: 4.2907

>T68185 WP_071162882.1 NZ_CP017811:c865584-865447 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAFLIEQWSNFTDFIRN

Download         Length: 138 bp

>T68185 NZ_CP017811:c865584-865447 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGTGTTCAACAGGCTTATACAGA
CATTGGCGCTTTTCTTATTGAGCAATGGTCTAATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT68185 WP_005649350.1 NZ_CP017811:c865784-865593 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT68185 NZ_CP017811:c865784-865593 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References