Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3798713..3800275 Replicon chromosome
Accession NZ_CP017810
Organism Thalassolituus oleivorans strain K188

Toxin (Protein)


Gene name hipA Uniprot ID A0A1L6KHL6
Locus tag CN03_RS17535 Protein ID WP_075274435.1
Coordinates 3798713..3800023 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1L6KHL7
Locus tag CN03_RS17540 Protein ID WP_075274436.1
Coordinates 3800027..3800275 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CN03_RS17520 3794369..3797122 + 2754 WP_075274432.1 ankyrin repeat domain-containing protein -
CN03_RS17525 3797277..3797852 - 576 WP_075274433.1 hypothetical protein -
CN03_RS17530 3797852..3798568 - 717 WP_075274434.1 AHH domain-containing protein -
CN03_RS17535 3798713..3800023 - 1311 WP_075274435.1 type II toxin-antitoxin system HipA family toxin Toxin
CN03_RS17540 3800027..3800275 - 249 WP_075274436.1 helix-turn-helix domain-containing protein Antitoxin
CN03_RS17545 3800358..3801002 + 645 WP_075274437.1 HipA domain-containing protein -
CN03_RS17550 3801199..3802431 - 1233 WP_075274626.1 HipA domain-containing protein -
CN03_RS18115 3802482..3802964 - 483 WP_083615734.1 helix-turn-helix transcriptional regulator -
CN03_RS17560 3803141..3804160 - 1020 WP_075274438.1 virulence RhuM family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3751687..3804160 52473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-43)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48710.65 Da        Isoelectric Point: 6.0561

>T68184 WP_075274435.1 NZ_CP017810:c3800023-3798713 [Thalassolituus oleivorans]
MAELTVALNGIPVAVLDKRTSGALSFRYLSEWLQRPSARPISLSLPLSDTSYQGEKVLNFFDNLLPDSESIRTRIQSTFR
VASSHPFDLLAAVGRDCIGAIQLYPLGENIPDVKQVISEPLTDADIENLLAGYQQAPLGMDDDHDFRISLAGAQEKTALL
WHQGGWQRPLGSTPTSHIFKLPIGFLEPRNIDLRLSGENEWLCLQILKEYGVPVPNAQLAQFGAQKALIVERFDRRWSSD
SQWLMRLPQEDFCQALGVSPALKYENHGGPSIQDGMKLLQGSQASNADRELFFKVQILFWLLAAIDGHAKNFSVFLEPDS
AYRMTPIYDVLSAYPLMAQGSLPAEKAKMAMSLKGKNRHYHWAKIEPRHFISTAGQIGYSTRRTMELMNEIVDMTEGVLA
RVKANLPEGFPVQVSQSIFDGVTFQSQRLNDFSLSL

Download         Length: 1311 bp

>T68184 NZ_CP017810:c3800023-3798713 [Thalassolituus oleivorans]
ATGGCTGAACTCACGGTTGCCCTTAATGGAATTCCTGTTGCTGTTCTCGATAAACGTACGTCAGGTGCGCTCAGTTTTCG
CTATCTATCGGAATGGTTACAACGCCCCAGTGCTCGACCAATTTCATTGTCACTGCCATTGTCTGATACTTCGTACCAAG
GCGAAAAGGTACTTAACTTCTTTGACAACTTGTTACCTGATTCGGAATCCATTCGAACGAGAATACAGTCGACATTTCGT
GTTGCGAGCAGCCACCCGTTCGATTTATTGGCTGCAGTAGGGCGCGATTGCATTGGCGCTATTCAGCTTTACCCTTTGGG
CGAAAATATTCCCGATGTAAAACAGGTGATATCTGAACCGCTAACCGACGCTGATATTGAAAACCTACTGGCAGGTTACC
AGCAGGCACCGCTCGGCATGGATGACGACCATGACTTTCGTATCTCACTGGCGGGTGCCCAAGAGAAGACAGCACTACTT
TGGCATCAGGGCGGTTGGCAAAGACCATTAGGCAGCACACCGACCAGTCATATATTCAAATTACCCATCGGATTTTTAGA
ACCTCGTAATATCGACCTACGCCTCAGTGGTGAAAACGAATGGCTGTGTCTGCAAATATTGAAAGAGTATGGAGTGCCAG
TACCGAACGCTCAATTGGCTCAGTTCGGTGCTCAGAAAGCACTGATCGTAGAGCGCTTTGATCGACGTTGGTCGTCAGAT
TCACAATGGCTAATGCGCCTTCCTCAGGAAGACTTTTGCCAAGCGCTGGGTGTATCGCCAGCACTTAAATATGAAAATCA
TGGCGGGCCAAGCATTCAAGACGGTATGAAACTGCTGCAAGGATCGCAAGCCTCAAATGCGGACAGAGAACTGTTTTTCA
AAGTGCAAATACTCTTTTGGCTATTAGCTGCGATTGACGGTCATGCAAAGAATTTCAGTGTGTTTCTAGAACCCGATTCT
GCTTATCGCATGACGCCCATTTATGATGTGCTTTCTGCTTATCCGTTAATGGCCCAAGGCAGTTTACCTGCTGAAAAAGC
AAAGATGGCTATGTCGCTTAAAGGCAAAAATCGTCACTATCATTGGGCAAAAATAGAACCTAGGCACTTTATCAGCACCG
CGGGGCAGATTGGGTATTCGACTAGGCGAACAATGGAGCTGATGAATGAAATCGTTGATATGACGGAGGGAGTATTAGCT
CGGGTTAAAGCAAACTTGCCCGAAGGCTTTCCAGTACAGGTGAGCCAATCAATTTTCGATGGCGTGACATTTCAGTCGCA
ACGGTTGAACGATTTTAGTTTGAGTTTGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9215.47 Da        Isoelectric Point: 6.4653

>AT68184 WP_075274436.1 NZ_CP017810:c3800275-3800027 [Thalassolituus oleivorans]
MKVTSIELLAEAMKQARKEQQLSQAAAADRIGIKQATVSAFENHPDGSRLNTLFKLLAALELELHITKRGDPADKNQWDQ
EW

Download         Length: 249 bp

>AT68184 NZ_CP017810:c3800275-3800027 [Thalassolituus oleivorans]
ATGAAAGTCACCTCCATCGAACTACTCGCTGAAGCGATGAAGCAAGCCAGAAAAGAGCAACAGCTCTCGCAGGCGGCAGC
AGCCGATAGAATAGGTATCAAGCAAGCCACCGTTTCAGCATTTGAGAATCATCCAGACGGAAGTCGTTTAAACACTTTAT
TCAAACTATTGGCCGCCTTAGAGCTTGAGTTGCACATAACTAAGCGCGGTGATCCAGCAGATAAAAACCAATGGGATCAG
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6KHL6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6KHL7

References