Detailed information of TA system TA068183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 2607310..2607820
• Replicon: chromosome
• Accession: NZ_CP017810
• Organism: Thalassolituus oleivorans strain K188

Toxin (Protein)

• Gene name: relB
• Uniprot ID: W8GA76
• Locus tag: CN03_RS12050
• Protein ID: WP_015486389.1
• Coordinates: 2607310..2607573 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: W8G613
• Locus tag: CN03_RS12055
• Protein ID: WP_015486388.1
• Coordinates: 2607566..2607820 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CN03_RS18340	2603912..2604070	+	159	WP_189270613.1	hypothetical protein	-
CN03_RS12025	2604310..2604900	-	591	WP_075273942.1	putative adenosine monophosphate-protein transferase Fic	-
CN03_RS12030	2604905..2605366	-	462	WP_075273943.1	hypothetical protein	-
CN03_RS12035	2605577..2605942	-	366	WP_075273944.1	VOC family protein	-
CN03_RS12050	2607310..2607573	-	264	WP_015486389.1	Txe/YoeB family addiction module toxin	Toxin
CN03_RS12055	2607566..2607820	-	255	WP_015486388.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CN03_RS12060	2607980..2608516	-	537	WP_083615691.1	N-acetyltransferase	-
CN03_RS12065	2608532..2609029	-	498	WP_075273948.1	hypothetical protein	-
CN03_RS12070	2609152..2610399	-	1248	WP_075273949.1	hypothetical protein	-
CN03_RS12075	2610966..2611415	+	450	WP_075273950.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2606854..2607213	359
	-	inside	Integron	-	-	2604905..2609029	4124

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10365.75 Da
• Isoelectric Point: 9.0098

>T68183 WP_015486389.1 NZ_CP017810:c2607573-2607310 [Thalassolituus oleivorans]
MSSRLLCWTDEAWNDYVYWQGQDKKTLKRINKLISDTKRSPFEGIGKPESLKENLSGFWSRRIDDTNRLVYAVDDKTLTI
ISCRYHY

Nucleotide

• Length: 264 bp

>T68183 NZ_CP017810:c2607573-2607310 [Thalassolituus oleivorans]
ATGAGTAGTAGGCTTCTTTGTTGGACCGATGAAGCTTGGAATGATTACGTTTACTGGCAAGGTCAGGACAAAAAGACATT
AAAGCGTATAAACAAATTAATCAGTGACACTAAGCGTTCACCATTTGAGGGTATTGGCAAGCCTGAGTCTCTTAAAGAAA
ATTTGTCAGGTTTCTGGTCACGCCGAATTGATGACACCAATCGTTTAGTTTATGCCGTTGATGATAAAACGCTAACCATA
ATATCGTGCAGGTATCATTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9373.51 Da
• Isoelectric Point: 5.0481

>AT68183 WP_015486388.1 NZ_CP017810:c2607820-2607566 [Thalassolituus oleivorans]
MRVVSFTEARNGLKAVLDSVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLKSPANAEHLNKSIAQYKSGKTTQRD
IVDE

Nucleotide

• Length: 255 bp

>AT68183 NZ_CP017810:c2607820-2607566 [Thalassolituus oleivorans]
ATGAGAGTTGTATCTTTTACTGAAGCAAGAAATGGATTAAAAGCTGTTTTAGACTCTGTCGTTAATGATGCAGACACCAC
GGTTATAACGCGTCGAGATTCAGAAGATGCGGTTGTAATGTCATTAGATTATTACAATAGTTTGATGGAAACAGTTCATT
TATTAAAGTCTCCTGCAAATGCAGAACATTTAAACAAATCAATAGCTCAATATAAAAGTGGCAAAACTACGCAAAGAGAT
ATAGTCGATGAGTAG

Structures

Toxin

• AlphaFold DB: W8GA76

Antitoxin

• AlphaFold DB: W8G613