Detailed information of TA system TA068179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 1009054..1010656
• Replicon: chromosome
• Accession: NZ_CP017810
• Organism: Thalassolituus oleivorans strain K188

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: CN03_RS04595
• Protein ID: WP_189270708.1
• Coordinates: 1009709..1010656 (+)
• Length: 316 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: A0A1L6KB50
• Locus tag: CN03_RS04590
• Protein ID: WP_075272973.1
• Coordinates: 1009054..1009659 (+)
• Length: 202 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CN03_RS04575	1004186..1005601	+	1416	WP_075272970.1	restriction endonuclease subunit S	-
CN03_RS04580	1005598..1006590	+	993	WP_075272971.1	DUF91 domain-containing protein	-
CN03_RS04585	1006889..1008853	+	1965	WP_075272972.1	DUF262 domain-containing protein	-
CN03_RS04590	1009054..1009659	+	606	WP_075272973.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
CN03_RS04595	1009709..1010656	+	948	WP_189270708.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
CN03_RS04600	1010798..1014085	+	3288	WP_075272975.1	type I restriction endonuclease subunit R	-
CN03_RS04610	1014634..1015116	-	483	WP_075274521.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-271)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (9-55)

Sequences

Toxin

Protein

• Length: 316 a.a.
• Molecular weight: 35633.77 Da
• Isoelectric Point: 5.4150

>T68179 WP_189270708.1 NZ_CP017810:1009709-1010656 [Thalassolituus oleivorans]
VTNKAASIRQKLLNLSRERGESFDFVLQQYAIQRLLYRLSVSEYHDQFLLKGAMLFSVWTGDLHRPTKDIDLLGFGSNDT
DVLVNDFKVICAIEADDGLIFDIESIQGVRIKEDSLYQGVRVTGFAHLEKAKIGLQVDIGFGDAVTPNARLATIPSFLDF
PAPIMKIYPVYTVIAEKFHAMVALGLFNSRIKDFYDIWMIAIHGLQEGDFLLGEDALDGTALDGTLLVSAIRSTFNRRNT
VMSPEMLSVFTAEFMQDTNKHKQWNAFLNKNRIVSDQSFENIQQGLRRFLEPAYQAAALGAEYPFKWDVSEGKWK

Nucleotide

• Length: 948 bp

>T68179 NZ_CP017810:1009709-1010656 [Thalassolituus oleivorans]
GTGACTAATAAAGCGGCGTCGATACGCCAAAAACTGCTGAACTTATCGCGTGAACGCGGTGAGTCATTTGATTTCGTGTT
ACAGCAGTATGCGATTCAGCGGCTATTGTATCGCTTGAGTGTGTCGGAGTATCACGATCAGTTTCTTTTGAAAGGGGCGA
TGTTATTTTCGGTTTGGACGGGAGATCTGCATCGTCCTACTAAAGATATTGATTTGTTGGGTTTTGGATCAAACGATACT
GATGTACTAGTCAATGATTTTAAAGTCATTTGTGCTATAGAAGCCGATGATGGTTTGATCTTTGATATTGAATCAATTCA
AGGTGTTCGAATTAAGGAAGACTCACTTTATCAAGGTGTGAGAGTCACAGGGTTTGCTCATTTAGAAAAAGCGAAAATAG
GTTTGCAAGTTGATATTGGTTTTGGCGATGCTGTCACGCCTAATGCTAGGCTGGCAACTATTCCGTCATTTTTAGATTTT
CCTGCTCCTATAATGAAGATCTATCCGGTTTATACGGTGATCGCTGAGAAGTTTCACGCCATGGTGGCGCTGGGTCTGTT
TAATAGTCGTATTAAAGATTTTTATGATATTTGGATGATTGCTATTCATGGCTTACAGGAAGGTGATTTTTTACTCGGCG
AGGATGCTCTCGATGGGACTGCTCTTGATGGTACTCTACTAGTCTCTGCCATTAGATCGACGTTCAATCGGCGGAATACG
GTGATGAGCCCAGAGATGCTGTCTGTTTTTACGGCTGAATTTATGCAAGATACGAACAAACATAAACAGTGGAATGCCTT
CTTGAATAAAAATCGAATCGTCAGTGATCAGTCTTTTGAAAATATACAGCAAGGGTTACGACGTTTTTTAGAGCCCGCTT
ATCAAGCAGCCGCCCTAGGCGCTGAATATCCTTTTAAGTGGGATGTCAGTGAAGGGAAATGGAAATAA

Antitoxin

Protein

• Length: 202 a.a.
• Molecular weight: 22824.76 Da
• Isoelectric Point: 10.2027

>AT68179 WP_075272973.1 NZ_CP017810:1009054-1009659 [Thalassolituus oleivorans]
MSKTSKRQQVINLAIQRGLIRPRDLLAHDLPKDYLNMLAREGVLVKLGRGLYQWPDREASRHQSLIEVAKLAPNGVVALL
SALSFHGLGTQNPFEVWLAIDRKSRRPRIHYPPVRFVTMSHEGLVEGVEQHKIDGVMVSVFCPAKTVADCFKYRNKIGLD
VALEALKDGWRAQMFTMDDLLRYAKVCRVAKVMQPYMESLG

Nucleotide

• Length: 606 bp

>AT68179 NZ_CP017810:1009054-1009659 [Thalassolituus oleivorans]
ATGTCTAAAACCTCAAAACGCCAACAAGTGATCAATCTCGCCATACAGCGAGGGCTTATTCGTCCGCGCGATTTGCTGGC
TCACGACTTGCCCAAAGACTACTTAAACATGTTGGCGCGTGAAGGCGTGTTGGTTAAGCTGGGCCGTGGTTTGTATCAAT
GGCCAGATCGTGAAGCCAGCCGCCACCAGTCTTTGATTGAGGTCGCTAAACTGGCACCTAATGGTGTGGTGGCACTGCTG
TCTGCTTTGAGTTTTCATGGCTTGGGTACACAAAATCCTTTTGAAGTTTGGTTGGCAATTGACCGCAAGTCGCGCCGTCC
TCGTATTCATTATCCGCCGGTGCGCTTTGTCACTATGTCTCATGAAGGCTTGGTTGAAGGTGTTGAGCAGCATAAAATCG
ATGGCGTAATGGTCTCGGTTTTTTGTCCGGCGAAAACCGTAGCCGATTGTTTTAAGTACCGTAATAAGATTGGGTTAGAC
GTCGCCCTAGAAGCGCTAAAGGATGGTTGGCGTGCACAAATGTTCACGATGGATGATCTGCTTAGGTACGCCAAGGTGTG
TCGTGTGGCGAAGGTTATGCAACCTTATATGGAGTCTTTGGGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1L6KB50