Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 578816..579324 Replicon chromosome
Accession NZ_CP017810
Organism Thalassolituus oleivorans strain K188

Toxin (Protein)


Gene name relE Uniprot ID W8G675
Locus tag CN03_RS02595 Protein ID WP_025264641.1
Coordinates 578816..579076 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1L6KA13
Locus tag CN03_RS02600 Protein ID WP_075272755.1
Coordinates 579073..579324 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CN03_RS02565 574518..575963 - 1446 WP_075272750.1 hypothetical protein -
CN03_RS02570 576013..576360 + 348 WP_075272751.1 DUF4112 domain-containing protein -
CN03_RS02575 576821..577540 + 720 WP_075272752.1 transposase -
CN03_RS02580 577574..577873 - 300 WP_075272753.1 type II toxin-antitoxin system RelE/ParE family toxin -
CN03_RS02585 577879..578136 - 258 WP_015485604.1 type II toxin-antitoxin system ParD family antitoxin -
CN03_RS02590 578584..578811 + 228 WP_075272754.1 hypothetical protein -
CN03_RS02595 578816..579076 - 261 WP_025264641.1 Txe/YoeB family addiction module toxin Toxin
CN03_RS02600 579073..579324 - 252 WP_075272755.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CN03_RS02605 580046..580240 + 195 WP_145926208.1 hypothetical protein -
CN03_RS02610 580288..581796 + 1509 WP_075272757.1 hypothetical protein -
CN03_RS02615 581845..583296 - 1452 WP_075272758.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10299.76 Da        Isoelectric Point: 9.5464

>T68178 WP_025264641.1 NZ_CP017810:c579076-578816 [Thalassolituus oleivorans]
MKLTFSSKAWEEYLYWQKTDKAMVKRINALIKDASRDPFEGLGKPEPLKHGLSGYWSRRINDEHRFVYKVSDDGLLIAQL
RYHYEY

Download         Length: 261 bp

>T68178 NZ_CP017810:c579076-578816 [Thalassolituus oleivorans]
ATGAAATTAACATTCTCCTCCAAGGCTTGGGAAGAGTACTTATATTGGCAAAAAACAGACAAAGCGATGGTGAAACGGAT
AAATGCTTTAATCAAAGATGCCTCTCGCGACCCTTTTGAGGGTCTAGGAAAACCCGAACCACTAAAGCATGGACTTTCTG
GTTATTGGTCTCGTCGTATTAATGATGAGCACCGGTTCGTATATAAAGTTTCCGATGATGGTCTTTTAATCGCTCAATTA
CGCTATCACTATGAGTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9163.48 Da        Isoelectric Point: 5.0636

>AT68178 WP_075272755.1 NZ_CP017810:c579324-579073 [Thalassolituus oleivorans]
MDAISYTAARANLAKTMEKVCNDHSPVIITRKSETPVVMISLADYQAMEETAYLLRSPANARHLLESIAELEAGKGTQRD
LIE

Download         Length: 252 bp

>AT68178 NZ_CP017810:c579324-579073 [Thalassolituus oleivorans]
ATGGACGCCATAAGTTACACAGCAGCCCGAGCAAATCTTGCCAAAACCATGGAAAAAGTCTGTAACGATCACTCGCCTGT
GATTATTACAAGAAAAAGCGAGACCCCCGTAGTTATGATCTCCCTTGCGGACTACCAAGCCATGGAGGAGACCGCCTACC
TTCTACGCTCTCCTGCAAACGCTAGACATCTGCTTGAATCCATTGCAGAACTCGAAGCTGGCAAAGGTACCCAGAGAGAC
TTAATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8G675

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6KA13

References