Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4773368..4774025 Replicon chromosome
Accession NZ_CP017802
Organism Raoultella ornithinolytica strain MG isolate MG01

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag BK817_RS22710 Protein ID WP_004867355.1
Coordinates 4773368..4773778 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag BK817_RS22715 Protein ID WP_004867358.1
Coordinates 4773759..4774025 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK817_RS22690 4769290..4771023 - 1734 WP_044347376.1 single-stranded-DNA-specific exonuclease RecJ -
BK817_RS22695 4771029..4771742 - 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BK817_RS22700 4771765..4772661 - 897 WP_015585784.1 site-specific tyrosine recombinase XerD -
BK817_RS22705 4772839..4773360 + 522 WP_004867353.1 flavodoxin FldB -
BK817_RS22710 4773368..4773778 - 411 WP_004867355.1 protein YgfX Toxin
BK817_RS22715 4773759..4774025 - 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
BK817_RS22720 4774322..4775305 + 984 WP_004867359.1 tRNA-modifying protein YgfZ -
BK817_RS22725 4775427..4776086 - 660 WP_004867362.1 hemolysin III family protein -
BK817_RS22730 4776248..4776559 - 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
BK817_RS22735 4776609..4777337 + 729 WP_004867368.1 MurR/RpiR family transcriptional regulator -
BK817_RS22740 4777457..4778890 + 1434 WP_071359760.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T68177 WP_004867355.1 NZ_CP017802:c4773778-4773368 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T68177 NZ_CP017802:c4773778-4773368 [Raoultella ornithinolytica]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCCTGGCGCTCACAGTGGTTCTCGCTGCTGCTGCACGGCATTGTGGCGGC
TATTGTGCTGCTGATGCCCTGGCCGCTGAGCTACACGCCGCTATGGCTATTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGTCGGGGGGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCG
GAATGGGAGATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGTCTGCAGGATATGCAAACGCGTCGCCG
CCAGCATCTGTGGATCGCTGCAGACAGTATGGACGCCAAAGAGTGGCGAGATCTGCGCCGGTTGGTGTTACAAAAACCGG
CACAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT68177 WP_004867358.1 NZ_CP017802:c4774025-4773759 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT68177 NZ_CP017802:c4774025-4773759 [Raoultella ornithinolytica]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCAGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGATACGCTCAGCGATGAAGACAAACAGCTGTTTATCCGTCTGTTAGAAAACGACGATCCGGATC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCGCAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References