Detailed information of TA system TA068168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3257679..3258592
• Replicon: chromosome
• Accession: NZ_CP017802
• Organism: Raoultella ornithinolytica strain MG isolate MG01

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: BK817_RS15630
• Protein ID: WP_004862779.1
• Coordinates: 3258119..3258592 (+)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A808Y7A4
• Locus tag: BK817_RS15625
• Protein ID: WP_004862777.1
• Coordinates: 3257679..3258122 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BK817_RS15590	3252917..3253393	+	477	WP_015584237.1	acid resistance repetitive basic protein Asr	-
BK817_RS15610	3254325..3255548	-	1224	WP_071359522.1	zinc metallochaperone GTPase ZigA	-
BK817_RS15615	3255744..3256526	-	783	WP_071359523.1	DUF3750 domain-containing protein	-
BK817_RS15620	3256924..3257490	+	567	WP_015584190.1	DJ-1/PfpI family protein	-
BK817_RS15625	3257679..3258122	+	444	WP_004862777.1	DUF2384 domain-containing protein	Antitoxin
BK817_RS15630	3258119..3258592	+	474	WP_004862779.1	RES domain-containing protein	Toxin
BK817_RS15635	3258673..3259452	-	780	WP_071359524.1	SDR family oxidoreductase	-
BK817_RS15640	3259445..3259762	-	318	WP_004862785.1	nuclear transport factor 2 family protein	-
BK817_RS15645	3259865..3260770	+	906	WP_004862787.1	LysR family transcriptional regulator	-
BK817_RS15650	3260798..3261703	-	906	WP_054829296.1	transcriptional regulator GcvA	-
BK817_RS15655	3261945..3262553	+	609	WP_032716409.1	glutathione S-transferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17523.84 Da
• Isoelectric Point: 5.0735

>T68168 WP_004862779.1 NZ_CP017802:3258119-3258592 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPNSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Nucleotide

• Length: 474 bp

>T68168 NZ_CP017802:3258119-3258592 [Raoultella ornithinolytica]
ATGATTTTCTATCGTCTGGTTACCGGCCGTTACGCCAGCGAAGCCTGGACGGGAAGCGGGGCCAACCAGTACGGCGGGCG
CTGGAATCACCAGGGACACCCGGCGGTCTATGTGTCCACTTCCATTGCCCTGGCGTCACTGGAGATCCTGGTTCACGTCA
AAAATGAGGCAATCCTCAACCAGTATCAGCTGTATAGTATCGAGATACCGAACAGCGAAGTGGAATCCCTCGATAAACAG
TGGTTACCGGATAACTGGCAAGAAAATCCGATGCCCGTTTCCACAATGGATCTGGGCACCGGCTGGCTACAGTCGGGCAG
CGGTCTGGCGCTGATGCTTCCCTCCTGCATTATTCCCTATGAAAACAACGCCATTTTAAACCCGCTGCATCCCGCGTTCA
GCGAGGCCCTGGCCTCCGTGCGTCAGTATCCCTTTACCTTTGATCCCCGCCTCGCACGCTCCACGCCCCTCTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16190.45 Da
• Isoelectric Point: 4.9405

>AT68168 WP_004862777.1 NZ_CP017802:3257679-3258122 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSILDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT68168 NZ_CP017802:3257679-3258122 [Raoultella ornithinolytica]
ATGAAAACCTGGGTTCCTGCAGAGCAACCTGCCGATAATGCGCTGTGGCGCTATGCCGGGCTACCGGCGAATCGGGGTAT
GCAGTTGATTGAGCTGCTGAGTATGGGATTACCGGTCAGCATTCTGGATAATATTCATGAGTGGACGGAAATGTCGAAAA
CCGACATTCTGCGCATCACCGGGATTAATGAGCGCAACGTTGCCCGGCGCAAGAGCGCGGGCGGCACGTTGACGCCAGGC
GAAAGCGAACGTGTGGCGCGTTTTGTCAGGGTCCTGGATACCGCCGTCGACTATTTTGGCAGCAAGCAGGATGCCTACGA
CTGGCTGCAGTCGCCGGTCAGAGGACTGGGCAATGTCGCCCCCATCGATCTGATTGCTACCGAGAGCGGCGCGCTGGAAG
TAACAGACCTGATTGGTCGCCTGGAACACGGCGTCTTTGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A808Y7A4